Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 410, 33-34 (1 March 2001) | doi:10.1038/35065201
Open Innovation Challenges
-
Methods of Modeling Adaptation in Populations
The analysis of adaptation with a population is a frequently encountered computational modeling scen...
-
Direct Molecular Detection of Proteins and Nucleic Acids
This Challenge is looking for novel approaches to protein and nucleic acid detection. This is an Id...
- More Challenges
- Powered by:
nature jobs
Research Fellow
- Beth Israel Deaconess Medical Center
- Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215
Gastroenterologist
- Wayne State University
- Detroit, Michigan, USA
Apoptosis: Baiting death inhibitors
Donald W. Nicholson
Abstract
Enzymes called caspases that start the process of programmed cell death can be dangerous if activated at the wrong time. A feat of self-restraint keeps one such caspase under control.
Most of the cell death that takes place in mammals occurs by apoptosis — the result of a dedicated biochemical pathway. At the heart of this pathway lies a family of protein-cleaving enzymes, the caspases, which normally lie dormant in healthy cells and become activated in response to diverse stimuli when cell death is required.
To read this story in full you will need to login or make a payment (see right).
