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Nature 410, 24-25 (1 March 2001) | doi:10.1038/35065180

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Cancer: An attractive force in metastasis

Lance A. Liotta

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In breast-cancer patients, secondary tumours often form in the lungs and bone marrow, for example, but rarely in the kidneys. The explanation for this bias involves soluble attractant molecules called chemokines.

The main cause of treatment failure and death for cancer patients is metastasis — the formation of secondary tumours in organs a long way from the original cancer. As long ago as the early nineteenth century, it was recognized that secondary tumours are seeded by cells released from the original tumour and ferried about the body in the lymphatic and blood circulations.