FIGURE 1. Cytogenetic analyses of sequence-integrated clones.

From the following article:

Integration of cytogenetic landmarks into the draft sequence of the human genome

The BAC Resource Consortium, V. G. Cheung, N. Nowak, W. Jang, I. R. Kirsch, S. Zhao, X.-N. Chen, T. S. Furey, U.-J. Kim, W.-L. Kuo, M. Olivier, J. Conroy, A. Kasprzyk, H. Massa, R. Yonescu, S. Sait, C. Thoreen, A. Snijders, E. Lemyre, J. A. Bailey, A. Bruzel, W. D. Burrill, S. M. Clegg, S. Collins, P. Dhami, C. Friedman, C. S. Han, S. Herrick, J. Lee, A. H. Ligon, S. Lowry, M. Morley, S. Narasimhan, K. Osoegawa, Z. Peng, I. Plajzer-Frick, B. J. Quade, D. Scott, K. Sirotkin, A. A. Thorpe, J. W. Gray, J. Hudson, D. Pinkel, T. Ried, L. Rowen, G. L. Shen-Ong, R. L. Strausberg, E. Birney, D. F. Callen, J.-F. Cheng, D. R. Cox, N. A. Doggett, N. P. Carter, E. E. Eichler, D. Haussler, J. R. Korenberg, C. C. Morton, D. Albertson, G. Schuler, P. J. de Jong & B. J. Trask

Nature 409, 953-958(15 February 2001)

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a, Using FISH, fluorescent signals are observed at cytogenetic bands (grey) where fragments of a sequence-tagged BAC hybridize (red). b, Clones selected on the basis of band location were used in FISH analyses to map the breakpoint of a translocation involving chromosomes 11 and 19 in a patient with multiple congenital malformations and mental retardation (DGAP012, http://dgap.harvard.edu). Clone CTD-3193o13 spans the breakpoint on chromosome 19; red signal is split between the derivative chomosome 11 and derivative 19 chromosomes and is also present on the normal chromosome 19. The GTG-banded karyotype for this patient is 46,XY,t(11;19)(p11.2;p13.3).

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