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Nature 409, 141-144 (11 January 2001) | doi:10.1038/35051677
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Senior Staff Scientist
- National Institute of Mental Health (NIMH)
- Bethesda, Maryland
Postdoctoral Position
- Max-Planck-Institute (MPI) of Immunobiology
- Freiburg Germany
Cancer: Death and methylation
Peter A. Jones
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Abstract
Malignant melanoma cells can resist committing suicide when attacked by chemotherapy. The explanation lies in the discovery that a key gene in the cell-death pathway is switched off in this cancer.
An ability to avoid committing suicide is one of the keys to a cancer cell's survival, whether it is spreading from one part of the body to another by metastasis or facing attack from chemotherapy. Malignant melanoma is a particularly nasty form of cancer in this respect.
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