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From the following article:

Identification of the platelet ADP receptor targeted by antithrombotic drugs

Gunther Hollopeter, Hans-Michael Jantzen, Diana Vincent, Georgia Li, Laura England, Vanitha Ramakrishnan, Ruey-Bing Yang, Paquita Nurden, Alan Nurden, David Julius & Pamela B. Conley

Nature 409, 202-207(11 January 2001)

doi:10.1038/35051599

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

P2Y12 is a G-protein-coupled receptor that responds to ADP.

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Figure 2

Currents stimulated by ADP in oocytes expressing hP2Y12 with Kir3.1 and 3.4 are inhibited by 2MeSAMP, C1330-7 or a thiol reagent.

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Figure 3

Activation of hP2Y12 in CHO cells inhibits adenylyl cyclase.

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Figure 4

P2Y12 receptor is selectively expressed in platelets and brain.

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Figure 5

A frame-shift mutation within the hP2Y12 gene is associated with a bleeding disorder.

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