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Nature 409, 33-34 (4 January 2001) | doi:10.1038/35051208

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DNA replication: SOS polymerases

Fumio Hanaoka

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The standard DNA-replicating machinery cannot copy damaged DNA, so SOS enzymes come to the rescue. It now seems, at least in some bacteria, that different enzymes are required for different types of damage.

Imagine that an injured person is carried into a hospital's emergency department. The doctor needs to assess the situation quickly, and to decide on the most appropriate treatment — stitches, a drug or maybe an operation?