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Nature 409, 33-34 (4 January 2001) | doi:10.1038/35051208
Open Innovation Challenges
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Direct Molecular Detection of Proteins and Nucleic Acids
This Challenge is looking for novel approaches to protein and nucleic acid detection. This is an Id...
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Methods of Modeling Adaptation in Populations
The analysis of adaptation with a population is a frequently encountered computational modeling scen...
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Organic Chemistry
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DNA replication: SOS polymerases
Fumio Hanaoka
Abstract
The standard DNA-replicating machinery cannot copy damaged DNA, so SOS enzymes come to the rescue. It now seems, at least in some bacteria, that different enzymes are required for different types of damage.
Imagine that an injured person is carried into a hospital's emergency department. The doctor needs to assess the situation quickly, and to decide on the most appropriate treatment — stitches, a drug or maybe an operation?
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