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Nature 408, 764-766 (14 December 2000) | doi:10.1038/35048748

Open Innovation Challenges

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Swimming against the tide

David Cyranoski1

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Toshio Yanagida rejects the conventional biophysical explanation of muscle contraction. No one doubts his technical genius, but could the debate he started ultimately hold back the field? David Cyranoski investigates.

Iconoclast, radical, technical wizard — these are just some of the descriptions that have been applied to Toshio Yanagida, host of last month's Frontiers in Molecular Motors Research symposium in Japan. Yanagida's technological brilliance has been crucial in developing methods to study what drives muscle contraction.