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Nature 408, 420-421 (23 November 2000) | doi:10.1038/35044177
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Diabetes: Gene therapy for rats and mice
Jerrold M. Olefsky
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Abstract
Delivery of an insulin-encoding gene into diabetic rats and mice has helped them to regulate their blood glucose levels. But there are still obstacles to overcome before this approach can be used in humans.
Type I diabetes is an autoimmune disease that begins in childhood or early
adulthood, and eventually causes complete destruction of the insulin-secreting 
-cells
in the pancreas1. The upshot is that patients with type I diabetes
produce absolutely no insulin.
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