Table of contents
Volume 408 Number 6810 pp275-388
Opinion
Ethics can boost science p275
A report from a European ethics committee gives a valuable summary of the issues surrounding stem-cell research. Debates over therapeutic cloning should not distract attention from central ethical concerns and alternative stem-cell techniques.
doi:10.1038/35042706
News
European panel rejects creation of human embryos for research p277
David Dickson
doi:10.1038/35042708
Online naming of species opens digital age for taxonomy p278
Henry Gee
Political uncertainty halts bioprospecting in Mexico p278
Rex Dalton
doi:10.1038/35042713
Climate talks face uncertainty over US strategy p279
Tony Reichhardt
doi:10.1038/35042716
Election impasse leaves science in the dark p279
Tony Reichhardt and Paul Smaglik
doi:10.1038/35042719
Row over fate of endangered monkeys p280
David Cyranoski
doi:10.1038/35042722
Fake finds reveal critical deficiency p280
David Cyranoski
doi:10.1038/35042725
Promise of Higgs fails to save CERN collider p281
Alison Abbott
doi:10.1038/35042728
Medical institute opens amid hopes of Kansas rebirth p281
Paul Smaglik
doi:10.1038/35042731
News Feature
Slimebusters p284
Bacteria do not always simply float around — more often they grow on surfaces in mucilaginous communities called biofilms. Working out how to block their formation or dismantle them could help treat life-threatening infections, says Marina Chicurel.
Marina Chicurel
doi:10.1038/35042737
Correspondence
Why are AIDS dissidents still making 15-year-old, long-refuted claims? p287
Martin Delaney
Mildest organochlorines still cause toxic pollution p287
Jonathan R. Latham
Ancestors knew how to harness horsepower . . . p287
François Sigaut
. . . so animals could pull their weight, and more p288
Michael R. Goe
Award organizers should have noted the paper p288
Justin Kruger
Fraud: retracted articles are still being cited p288
Juan Miguel Campanario
doi:10.1038/35042753
Book Reviews
Technology's tortoise and hare p289
The Sociological dynamics are now right for the electric car to eclipse its rival.
Stanford Ovshinsky reviews The Electric Vehicle and the Burden of History by David A. Kirsch
doi:10.1038/35042628
A burden undeserved p289
doi:10.1038/35042630
Physics of the money markets p290
Blake LeBaron reviews An Introduction to Econophysics Rosario N. Mantegna and H. EugeneStanley
doi:10.1038/35042633
A cosmological bouquet p291
Giovanni F. Bignami reviews The Book of the Cosmos: Imagining the Universe from Heraclitus to Hawking
doi:10.1038/35042636
Science in culture p292
Mark A. Elgar reviews
doi:10.1038/35042639
Millennium Essay
Nice work — but is it science? p293
Untestable ecological theory won't help solve environmental problems.
Jim Smith
doi:10.1038/35042642
Futures
At the zoo p295
The last two baseline humans in captivity have bred successfully.
Warren Ellis
News and Views
Plotting the pyramids p297
There is no evidence in ancient texts that Egyptians used astronomical knowledge in building the pyramids. But analysis of the night sky in 2500 bc could help explain how the pyramid builders knew the direction of true north.
Owen Gingerich
doi:10.1038/35042648
Speciation: Fish found in flagrante delicto p298
Genetic analysis of cichlid fish in Nicaraguan lakes reveals a possible case of repeated sympatric speciation: the creation of two species from one in the same environment.
Mark Kirkpatrick
doi:10.1038/35042651
Nanothermodynamics: Breathing life into an old model p299
A classic theory of magnetism has been modernized by a novel use of thermodynamics. The theory can now describe the behaviour of ferromagnetic materials at higher temperatures.
Tom Giebultowicz
doi:10.1038/35042654
Global change: It's not a gas p301
Nitrous oxide is a greenhouse gas and also contributes to ozone loss. It seems that fertilizer run-off into coastal waters stimulates its production — at least to the west of India.
Hermann W. Bange
doi:10.1038/35042656
Medicine: Cardiac arrest can be less of a gamble p302
Tim Lincoln
doi:10.1038/35042660
Evolutionary biology: Mitochondrial genes on the move p302
In flowering plants, genes have frequently been transferred from mitochondria to the cell nucleus by way of a remarkable evolutionary rapid-transit system.
Michael W. Gray
doi:10.1038/35042663
Astronomy: The legacy of a lonely life p303
Leslie Sage
doi:10.1038/35042665
100 and 50 years ago p305
Neural engineering: Real brains for real robots p305
Neural signals from the brains of monkeys have been used to drive the movement of robotic arms. The ultimate objective of such work is to design controllable prosthetic limbs.
Sandro Mussa-Ivaldi
doi:10.1038/35042670
News and Views Feature
Surfing the p53 network p307
The p53 tumour-suppressor gene integrates numerous signals that control cell life and death. As when a highly connected node in the Internet breaks down, the disruption of p53 has severe consequences.
Bert Vogelstein, David Lane and Arnold J. Levine
doi:10.1038/35042675
Brief Communications
Tracing the geographical origin of cocaine p311
Cocaine carries a chemical fingerprint from the region where the coca was grown.
James R. Ehleringer, John F. Casale, Michael J. Lott and Valerie L. Ford
doi:10.1038/35042680
First paragraph | Full Text | PDF (159K)
Archaeology: Detecting milk proteins in ancient pots p312
Oliver Craig, Jacqui Mulville, Mike Parker Pearson, Robert Sokol, Keith Gelsthorpe, Rebecca Stacey and Matthew Collins
First paragraph | Full Text | PDF (96K)
Review
Feedback control of intercellular signalling in development p313
Matthew Freeman
doi:10.1038/35042500
Abstract | Full Text | PDF (246K)
Articles
Ancient Egyptian chronology and the astronomical orientation of pyramids p320
Kate Spence
doi:10.1038/35042510
Abstract | Full Text | PDF (198K)
See also: News and Views by Gingerich
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference p325
Andrew G. Fraser, Ravi S. Kamath, Peder Zipperlen, Maruxa Martinez-Campos, Marc Sohrmann and Julie Ahringer
doi:10.1038/35042517
Abstract | Full Text | PDF (189K) | Supplementary information
Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III p331
Pierre Gönczy, Christophe Echeverri, Karen Oegema, Alan Coulson, Steven J. M. Jones, Richard R. Copley, John Duperon, Jeff Oegema, Michael Brehm, Etienne Cassin, Eva Hannak, Matthew Kirkham, Silke Pichler, Kathrin Flohrs, Anoesjka Goessen, Sebastian Leidel, Anne-Marie Alleaume, Cécilie Martin, Nurhan Özlü, Peer Bork and Anthony A. Hyman
doi:10.1038/35042526
Abstract | Full Text | PDF (254K) | Supplementary information
Letters to Nature
Mean-field cluster model for the critical behaviour of ferromagnets p337
Ralph V. Chamberlin
doi:10.1038/35042534
First paragraph | Full Text | PDF (168K)
See also: News and Views by Giebultowicz
Universal quantum computation with the exchange interaction p339
D. P. DiVincenzo, D. Bacon, J. Kempe, G. Burkard and K. B. Whaley
doi:10.1038/35042541
First paragraph | Full Text | PDF (172K)
Kondo physics in carbon nanotubes p342
Jesper Nygård, David Henry Cobden and Poul Erik Lindelof
doi:10.1038/35042545
First paragraph | Full Text | PDF (409K)
Increased marine production of N2O due to intensifying anoxia on the Indian continental shelf p346
S. W. A. Naqvi, D. A. Jayakumar, P. V. Narvekar, H. Naik, V. V. S. S. Sarma, W. D'Souza, S. Joseph and M. D. George
doi:10.1038/35042551
First paragraph | Full Text | PDF (663K) | Supplementary information
See also: News and Views by Bange
Microseismological evidence for a changing wave climate in the northeast Atlantic Ocean p349
I. Grevemeyer, R. Herber and H.-H. Essen
doi:10.1038/35042558
First paragraph | Full Text | PDF (141K)
Fine-scale genetic structuring on Manacus manacus leks p352
Lisa Shorey, Stuart Piertney, Jon Stone and Jacob Höglund
doi:10.1038/35042562
First paragraph | Full Text | PDF (119K) | Supplementary information
Repeated, recent and diverse transfers of a mitochondrial gene to the nucleus in flowering plants p354
Keith L. Adams, Daniel O. Daley, Yin-Long Qiu, James Whelan and Jeffrey D. Palmer
doi:10.1038/35042567
First paragraph | Full Text | PDF (202K) | Supplementary information
See also: News and Views by Gray
Imagery neurons in the human brain p357
Gabriel Kreiman, Christof Koch and Itzhak Fried
doi:10.1038/35042575
First paragraph | Full Text | PDF (289K)
Real-time prediction of hand trajectory by ensembles of cortical neurons in primates p361
Johan Wessberg, Christopher R. Stambaugh, Jerald D. Kralik, Pamela D. Beck, Mark Laubach, John K. Chapin, Jung Kim, S. James Biggs, Mandayam A. Srinivasan and Miguel A. L. Nicolelis
doi:10.1038/35042582
First paragraph | Full Text | PDF (315K) | Supplementary information
See also: News and Views by Mussa-Ivaldi
A regulator of transcriptional elongation controls vertebrate neuronal development p366
Su Guo, Yuki Yamaguchi, Sarah Schilbach, Tadashi Wada, James Lee, Audrey Goddard, Dorothy French, Hiroshi Handa and Arnon Rosenthal
doi:10.1038/35042590
First paragraph | Full Text | PDF (383K) | Supplementary information
ClC-5 Cl--channel disruption impairs endocytosis in a mouse model for Dent's disease p369
Nils Piwon, Willy Günther, Michael Schwake, Michael R. Bösl and Thomas J. Jentsch
doi:10.1038/35042597
First paragraph | Full Text | PDF (375K) | Supplementary information
The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5 p374
Letizia Lanzetti, Vladimir Rybin, Maria Grazia Malabarba, Savvas Christoforidis, Giorgio Scita, Marino Zerial and Pier Paolo Di Fiore
doi:10.1038/35042605
First paragraph | Full Text | PDF (292K) | Supplementary information
Deacetylation of p53 modulates its effect on cell growth and apoptosis p377
Jianyuan Luo, Fei Su, Delin Chen, Ariel Shiloh and Wei Gu
doi:10.1038/35042612
First paragraph | Full Text | PDF (207K) | Supplementary information
Insights into SCF ubiquitin ligases from the structure of the Skp1–Skp2 complex p381
Brenda A. Schulman, Andrea C. Carrano, Philip D. Jeffrey, Zachary Bowen, Elspeth R. E. Kinnucan, Michael S. Finnin, Stephen J. Elledge, J. Wade Harper, Michele Pagano and Nikola P. Pavletich
doi:10.1038/35042620
First paragraph | Full Text | PDF (367K) | Supplementary information
New on the Market
Cultural references p387
The latest gadgets and media for cell and tissue culture.
doi:10.1038/35042687