Table of contents


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Opinion

A fresh start in space p121

Whatever their previous scepticism, scientists should embrace the opportunity to see whether the International Space Station can address important research questions. NASA's decisions on its microgravity research are a step in the right direction.

doi:10.1038/35041727


Biotechnology battleground p121

An independent inquiry is needed to restore morale at an international biotechnology research centre in New Delhi.

doi:10.1038/35041729


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News

Emphasis of NASA's microgravity research shifts to space biology p123

Tony Reichhardt

doi:10.1038/35041731


US grad students win union rights p123

Paul Smaglik

doi:10.1038/35041735


Mexican science waits to see if election promises are met p124

Marina Chicurel

doi:10.1038/35041737


Pesticide use linked to Parkinson's disease p125

David Adam

doi:10.1038/35041740


Unprecedented gift boosts basic physics in Canada p125

David Spurgeon

doi:10.1038/35041743


Court young French postdocs, says petition. . . p126

Declan Butler

doi:10.1038/35041746


. . .as changes at the top suggest action ahead p126

Declan Butler

doi:10.1038/35041748


Japan's GM corn will undergo tests p126

David Cyranoski

doi:10.1038/35041751


Indian biotech centre rocked by controversy p127

K. S. Jayaraman

doi:10.1038/35041753


News in brief p128

doi:10.1038/35041757


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News Feature

Structures by numbers p130

Advances in automation and genome sequence data will allow new protein structures to be produced faster than ever before. As the era of structural genomics unfolds, it could revolutionize drug discovery, says Alison Abbott.

Alison Abbott

doi:10.1038/35041760


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Correspondence

Farming will only be sustainable when local people are truly involved p133

Willy H. Verheye

doi:10.1038/35041765


Guidelines work better than animal welfare law p133

Mary J. C. Hendrix

doi:10.1038/35041767


Wrong signals about alliance's scope and aim p133

Alfred G. Gilman

doi:10.1038/35041769


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Commentary

Helping western forests heal p135

The prognosis is poor for US forest ecosystems.

doi:10.1038/35041641


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Book Reviews

Anthropologists under fire p137

Charges of abuse of a remote tribal people must be answered.

Robert N. Proctor reviews Darkness in El Dorado: How Scientists and Journalists Devastated the Amazon by Patrick Tierney

doi:10.1038/35041611


New in paperback p138

doi:10.1038/35041615


Across the industrial divide p139

Anthony Vice reviews The Great Divergence: China, Europe and the Making of the Modern World Economy by Kenneth Pomeranz

doi:10.1038/35041617


Science in culture p140

Roy Porter reviews

doi:10.1038/35041620


Top

Millennium Essay

The sounds of silence p141

No news about cancer prevention is good news.

Robert C. Young

doi:10.1038/35041645


Top

Futures

Ars longa, vita brevis p143

Last remaining astronomy department disbanded.

James Alan Gardner

doi:10.1038/35041648


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News and Views

Ancient food for thought p145

Archaeological evidence of unexpected modes of food production in the tropics of lowland Central and South America carries lessons for modern farmers and students of crop-plant evolution.

Warwick Bray

doi:10.1038/35041651


Signal transduction: A most interesting factor p146

The effects of the signalling molecule MIF are quite well understood, but how it works remains a mystery. Some of the pathways behind its activity have now been revealed — with surprising results.

Richard Bucala

doi:10.1038/35041654


100 and 50 years ago p147

doi:10.1038/35041657


Aquatic ecology: A lake's life is not its own p149

George W. Kling

doi:10.1038/35041659


RNA silencing: Moving targets p150

Viruses have evolved several strategies to attack plants, but the plants keep hitting back. So the viruses have upped the ante by stopping the plants' immune response from spreading to uninfected tissues.

James C. Carrington

doi:10.1038/35041662


Nanotechnology: In control of molecular motion p151

Nature leads the way when it comes to motors on a molecular scale. But chemists are in hot pursuit, designing controllable structures that can mimic muscles or rotary motors.

Ben L. Feringa

doi:10.1038/35041665


Oceanography: Flow charts p153

Detlef Stammer

doi:10.1038/35041669


Computational neuroscience: Intimate attention p154

If we are to perceive a visual figure, we need to direct our attention towards it. The more we discover about this ability, the more impressive it seems.

Jochen Braun

doi:10.1038/35041672


Global change: That sinking feeling p155

The land and sea soak up much of the carbon dioxide emitted into the atmosphere. But one set of simulations suggests that global warming could greatly impair this ability.

Jorge Sarmiento

doi:10.1038/35041676


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Brief Communications

Invasive alga reaches California p157

The alga has been identified that threatens to smother Californian coastal ecosystems.

O. Jousson, J. Pawlowski, L. Zaninetti, F. W. Zechman, F. Dini, G. Di Guiseppe, R. Woodfield, A. Millar and A. Meinesz

doi:10.1038/35041623


Imaging: Phase radiography with neutrons p158

B. E. Allman, P. J. McMahon, K. A. Nugent, D. Paganin, D. L. Jacobson, M. Arif and S. A. Werner

doi:10.1038/35041626


Scaling: Rivers, blood and transportation networks p159

Page R. Painter

doi:10.1038/35041631


Scaling: Rivers, blood and transportation networks p159

Peter K. Haff

doi:10.1038/35041633


reply: Rivers, blood and transportation networks p160

Jayanth R. Banavar, Amos Maritan and Andrea Rinaldo

doi:10.1038/35041635


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Articles

Chemical and biological trends during lake evolution in recently deglaciated terrain p161

Daniel R. Engstrom, Sherilyn C. Fritz, James E. Almendinger and Stephen Juggins

doi:10.1038/35041500

See also: News and Views by Kling


Structure and assembly of the Alu domain of the mammalian signal recognition particle p167

Oliver Weichenrieder, Klemens Wild, Katharina Strub and Stephen Cusack

doi:10.1038/35041507


Top

Letters to Nature

New high-pressure phases of lithium p174

M. Hanfland, K. Syassen, N. E. Christensen and D. L. Novikov

doi:10.1038/35041515


Reversible phase transitions in polymer gels induced by radiation forces p178

Saulius Juodkazis, Naoki Mukai, Ryosuke Wakaki, Akira Yamaguchi, Shigeki Matsuo and Hiroaki Misawa

doi:10.1038/35041522


An enantiomerically pure hydrogen-bonded assembly p181

Leonard J. Prins, Feike De Jong, Peter Timmerman and David N. Reinhoudt

doi:10.1038/35041530


Acceleration of global warming due to carbon-cycle feedbacks in a coupled climate model p184

Peter M. Cox, Richard A. Betts, Chris D. Jones, Steven A. Spall and Ian J. Totterdell

doi:10.1038/35041539

See also: News and Views by Sarmiento


Offset of the potential carbon sink from boreal forestation by decreases in surface albedo p187

Richard A. Betts

doi:10.1038/35041545


An artificial landscape-scale fishery in the Bolivian Amazon p190

Clark L. Erickson

doi:10.1038/35041555

See also: News and Views by Bray


Spatial synchronization of vole population dynamics by predatory birds p194

Rolf A. Ims and Harry P. Andreassen

doi:10.1038/35041562


Tracking an object through feature space p196

Erik Blaser, Zenon W. Pylyshyn and Alex O. Holcombe

doi:10.1038/35041567

See also: News and Views by Braun


Distinct functions of the two isoforms of dopamine D2 receptors p199

Alessandro Usiello, Ja-Hyun Baik, Françoise Rougé-Pont, Roberto Picetti, Andrée Dierich, Marianne LeMeur, Pier Vincenzo Piazza and Emiliana Borrelli

doi:10.1038/35041572


Regulation of repulsion versus adhesion by different splice forms of an Eph receptor p203

Johan Holmberg, Diana L. Clarke and Jonas Frisén

doi:10.1038/35041577


Functional interaction of phytochrome B and cryptochrome 2 p207

Paloma Más, Paul F. Devlin, Satchidananda Panda and Steve A. Kay

doi:10.1038/35041583


Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1 p211

Robert Kleemann, Angelika Hausser, Georg Geiger, Ralf Mischke, Anke Burger-Kentischer, Oliver Flieger, Franz-Josef Johannes, Thierry Roger, Thierry Calandra, Aphrodite Kapurniotu, Matthias Grell, Doris Finkelmeier, Herwig Brunner and Jürgen Bernhagen

doi:10.1038/35041591

See also: News and Views by Bucala


Cell-cycle-regulated DNA double-strand breaks in somatic hypermutation of immunoglobulin genes p216

F. Nina Papavasiliou and David G. Schatz

doi:10.1038/35041599


PCNA connects DNA replication to epigenetic inheritance in yeast p221

Zhiguo Zhang, Kei-ichi Shibahara and Bruce Stillman

doi:10.1038/35041601


A transcription reinitiation intermediate that is stabilized by activator p225

Natalya Yudkovsky, Jeffrey A. Ranish and Steven Hahn

doi:10.1038/35041603


Top

Insight

foreword

Ageing p231

doi:10.1038/35041679


review article

Why do we age? p233

Thomas B. L. Kirkwood and Steven N. Austad

doi:10.1038/35041682


Oxidants, oxidative stress and the biology of ageing p239

Toren Finkel and Nikki J. Holbrook

doi:10.1038/35041687


The age of cancer p248

Ronald A. DePinho

doi:10.1038/35041694


Genetic pathways that regulate ageing in model organisms p255

Leonard Guarente and Cynthia Kenyon

doi:10.1038/35041700


Lessons from human progeroid syndromes p263

George M. Martin and Junko Oshima

doi:10.1038/35041705


commentary

The future of ageing p267

Leonard Hayflick

doi:10.1038/35041709


Top

New on the Market

Resistance movement p271

Immunology and immunochemicals as tools and for their own sake.

doi:10.1038/35041637


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Careers and Recruitment

Structural genomics — from cottage industry to industrial revolution p273

As the new discipline of structural genomics takes off, the demand for a wide variety of skilled workers is set to rise, says Diane Gershon.

Diane Gershon

doi:10.1038/35041771


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