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Signal transduction

A most interesting factor

The effects of the signalling molecule MIF are quite well understood, but how it works remains a mystery. Some of the pathways behind its activity have now been revealed — with surprising results.

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Figure 1: Pathways by which MIF (macrophage migration inhibitory factor) may regulate inflammation and the proliferation of target cells.

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Correspondence to Richard Bucala.

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Bucala, R. A most interesting factor. Nature 408, 146–147 (2000). https://doi.org/10.1038/35041654

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