Insight
Nature 408, 263-266 (9 November 2000) | doi:10.1038/35041705
Lessons from human progeroid syndromes
George M. Martin1,2 and Junko Oshima1
Abstract
A number of human genes have been identified in which mutations can lead to the accelerated emergence of features of senescence. Studies of these genes, and of the functions of their protein products, may lead to a clearer understanding of the nature of senescence, and could provide clues for ways in which ageing might be retarded.
- Department of Pathology, University of Washington, Seattle, Washington 98195, USA
- Department of Genetics, University of Washington, Seattle, Washington 98195, USA