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Nature 408, 37-38 (2 November 2000) | doi:10.1038/35040669;
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Small but mighty timekeepers
How is the timing of major developmental transitions in animals genetically controlled? How, for instance, does a larva know when to transform into an adult? One possible answer was suggested by the discovery of 'heterochronic' mutations in a small, intensely studied roundworm, the nematode Caenorhabditis elegans. These mutations, in a series of genes, either advance or retard the schedule of many developmental events as the worm progresses through its larval stages.
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