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Nature 407, 796-801 (12 October 2000) | doi:10.1038/35037734
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Organic Chemistry
- Praj Matrix - Praj Industries Ltd
- Pune, Maharashtra Pune-411021 India
Gastrointestinal Pathologist
- Brigham and Women's Hospital
- Boston, MA
review article Apoptosis in development
Pascal Meier1,3, Andrew Finch2 & Gerard Evan2
Abstract
Essential to the construction, maintenance and repair of tissues is the ability to induce suicide of supernumerary, misplaced or damaged cells with high specificity and efficiency. Study of three principal organisms — the nematode, fruitfly and mouse — indicate that cell suicide is implemented through the activation of an evolutionarily conserved molecular programme intrinsic to all metazoan cells. Dysfunctions in the regulation or execution of cell suicide are implicated in a wide range of developmental abnormalities and diseases.
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