Opinion

In defence of animal research p659

The use of animals in laboratory research needs championing more than ever. Those defending it need to reflect discussions within the research community and engage positively with issues of public concern.

doi:10.1038/35037756

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Blurred budget is bad news p659

Spain's government should stop shooting itself in the foot.

doi:10.1038/35037758

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News

Medicine Nobel goes to raiders of the brain's chemical secrets p661

Alison Abbott

doi:10.1038/35037760

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Fathers of electronic revolution are rewarded p662

Liesbeth Venema

doi:10.1038/35037763

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Plastics that conduct win inventors chemistry prize p662

David Adam

doi:10.1038/35037767

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Gore and Bush back rise in science spending p663

ColinMacilwain

doi:10.1038/35037769

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Project offers free mouse sequence p663

Paul Smaglik and Alison Abbott

doi:10.1038/35037772

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Anger as Spain boosts R&D figures with defence money p664

Xavier Bosch

doi:10.1038/35037775

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Astrometry mission wins German approval p665

Alison Abbott

doi:10.1038/35037779

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Ig Nobel glory for levitating frogs and collapsing toilets p665

Steve Nadis

doi:10.1038/35037782

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News in brief p666

doi:10.1038/35037785

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News Feature

Science for art's sake p668

In several labs around Boston, the techniques of genetic and tissue engineering are being used in the name of art. Steve Nadis asks the artists and scientists involved what they gain from this fusion of high culture and cell culture.

Steve Nadis

doi:10.1038/35037788

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Correspondence

Poorly conducted (or reported) animal tests put humans at risk p671

Victoria Hampshire

doi:10.1038/35037798

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Why don't creationists use private schools? p671

Jeffrey M. Marcus and Joanne E. Seiff

doi:10.1038/35037800

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Survival on the edge: the tube worm's strategy p671

John D. Rummel

doi:10.1038/35037802

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Book Reviews

Activism, scientists and sociobiology p673

A scientific movement honed by capitalists, Marxists — and the Vietnam War.

David L. Hull reviews Defenders of the Truth: The Battle for Science in the Sociobiology Debate and Beyond by Ullica Segerstråle

doi:10.1038/35037645

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Sign of the times p673

doi:10.1038/35037647

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The climate of fashion p674

doi:10.1038/35037650

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Dowsing the human volcano p674

Paul Crutzen reviews Something New Under the Sun: An Environmental History of the Twentieth-Century World by J. R. McNeill

doi:10.1038/35037653

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Icy displays from before time p675

Dale P. Cruikshank reviews Comet Science: The Study of Remnants from the Birth of the Solar System by Jacques Crovisier and Thérèse Encrenaz

doi:10.1038/35037655

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Science in culture p676

Philip Ball reviews

doi:10.1038/35037658

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Millennium Essay

A victim of truth p677

Vitalism was an attempt to reconcile rationality with a sense of wonder.

Sunetra Gupta

doi:10.1038/35037708

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Futures

Win a Nobel prize! p679

Wealth, chicks, guys, the secrets of the Universe — they can all be yours.

Vernor Vinge

doi:10.1038/35037684

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News and Views

Electrochemistry: Making a potential difference p681

To reduce our use of fossil fuels we will need cheap and safe batteries to run electric vehicles and store energy — magnesium batteries may be the answer.

George E. Blomgren

doi:10.1038/35037687

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Computational neuroscience: Building blocks of movement p682

Zoubin Ghahramani

doi:10.1038/35037690

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Conservation biology: Seeds of doubt p683

Peter D. Moore

doi:10.1038/35037693

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Oceanography: Stirring times in the Southern Ocean p685

Sallie W. Chisholm

doi:10.1038/35037696

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100 and 50 years ago p686

doi:10.1038/35037699

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DNA repair: Guarding against mutation p687

Richard D. Kolodner

doi:10.1038/35037701

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Evolutionary biology: Use it or lose it p689

Robert D. Holt

doi:10.1038/35037703

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Daedalus p690

David Jones

doi:10.1038/35037706

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Brief Communications

Before striking gold in gold-ruby glass p691

The chemistry of the magic ingredient in this ancient glass is no longer a mystery.

F. E. Wagner, S. Haslbeck, L. Stievano, S. Calogero, Q. A. Pankhurst and K. -P. Martinek

doi:10.1038/35037661

First paragraph | Full Text | PDF (211K)

Social insects: Facultative worker policing in a wasp p692

Kevin R. Foster and Francis L. W. Ratnieks

doi:10.1038/35037665

First paragraph | Full Text | PDF (717K)

Embryonic development: Maternal effect of Hsf1 on reproductive success p693

E. Christians, A. A. Davis, S. D. Thomas and I. J. Benjamin

doi:10.1038/35037669

First paragraph | Full Text | PDF (676K)

Biodiversity: Coexistence and resource competition p694

Per Lundberg, Esa Ranta, Veijo Kaitala and Niclas Jonzén

doi:10.1038/35037672

First paragraph | Full Text | PDF (81K)

reply: Coexistence and resource competition p694

Jef Huisman and Franz J. Weissing

doi:10.1038/35037674

First paragraph | Full Text | PDF (81K)

Articles

A mesoscale phytoplankton bloom in the polar Southern Ocean stimulated by iron fertilization p695

Philip W. Boyd, Andrew J. Watson, Cliff S. Law, Edward R. Abraham, Thomas Trull, Rob Murdoch, Dorothee C. E. Bakker, Andrew R. Bowie, K. O. Buesseler, Hoe Chang, Matthew Charette, Peter Croot, Ken Downing, Russell Frew, Mark Gall, Mark Hadfield, Julie Hall, Mike Harvey, Greg Jameson, Julie LaRoche, Malcolm Liddicoat, Roger Ling, Maria T. Maldonado, R. Michael McKay, Scott Nodder, Stu Pickmere, Rick Pridmore, Steve Rintoul, Karl Safi, Philip Sutton, Robert Strzepek, Kim Tanneberger, Suzanne Turner, Anya Waite and John Zeldis

doi:10.1038/35037500

Abstract | Full Text | PDF (409K)

See also: News and Views by Chisholm

Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA p703

Galina Obmolova, Changill Ban, Peggy Hsieh and Wei Yang

doi:10.1038/35037509

Abstract | Full Text | PDF (745K) | Supplementary information

See also: News and Views by Kolodner

The crystal structure of DNA mismatch repair protein MutS binding to a GT mismatch p711

Meindert H. Lamers, Anastassis Perrakis, Jacqueline H. Enzlin, Herrie H. K. Winterwerp, Niels de Wind and Titia K. Sixma

doi:10.1038/35037523

Abstract | Full Text | PDF (687K) | Supplementary information

See also: News and Views by Kolodner

Letters to Nature

Dynamics of singularities in a constrained elastic plate p718

Arezki Boudaoud, Pedro Patrício, Yves Couder and Martine Ben Amar

doi:10.1038/35037535

First paragraph | Full Text | PDF (602K)

Interconversion of single and double helices formed from synthetic molecular strands p720

Volker Berl, Ivan Huc, Richard G. Khoury, Michael J. Krische and Jean-Marie Lehn

doi:10.1038/35037545

First paragraph | Full Text | PDF (485K) | Supplementary information

Prototype systems for rechargeable magnesium batteries p724

D. Aurbach, Z. Lu, A. Schechter, Y. Gofer, H. Gizbar, R. Turgeman, Y. Cohen, M. Moshkovich and E. Levi

doi:10.1038/35037553

First paragraph | Full Text | PDF (317K)

See also: News and Views by Blomgren

Importance of stirring in the development of an iron-fertilized phytoplankton bloom p727

Edward R. Abraham, Cliff S. Law, Philip W. Boyd, Samantha J. Lavender, Maria T. Maldonado and Andrew R. Bowie

doi:10.1038/35037555

First paragraph | Full Text | PDF (225K)

See also: News and Views by Chisholm

Effect of iron supply on Southern Ocean CO₂ uptake and implications for glacial atmospheric CO₂ p730

A. J. Watson, D. C. E. Bakker, A. J. Ridgwell, P. W. Boyd and C. S. Law

doi:10.1038/35037561

First paragraph | Full Text | PDF (253K) | Supplementary information

See also: News and Views by Chisholm

The possible subduction of continental material to depths greater than 200 km p734

Kai Ye, Bolin Cong and Danian Ye

doi:10.1038/35037566

First paragraph | Full Text | PDF (211K) | Supplementary information

The population genetics of ecological specialization in evolving Escherichia coli populations p736

Vaughn S. Cooper and Richard E. Lenski

doi:10.1038/35037572

First paragraph | Full Text | PDF (132K)

See also: News and Views by Holt

Natural selection and sympatric divergence in the apple maggot Rhagoletis pomonella p739

Kenneth E. Filchak, Joseph B. Roethele and Jeffrey L. Feder

doi:10.1038/35037578

First paragraph | Full Text | PDF (160K) | Supplementary information

Learning of action through adaptive combination of motor primitives p742

Kurt A. Thoroughman and Reza Shadmehr

doi:10.1038/35037588

First paragraph | Full Text | PDF (306K)

See also: News and Views by Ghahramani

Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor p747

Véronique Corset, Kim Tuyen Nguyen-Ba-Charvet, Christelle Forcet, Emmanuel Moyse, Alain Chédotal and Patrick Mehlen

doi:10.1038/35037600

First paragraph | Full Text | PDF (258K)

Somatic support cells restrict germline stem cell self-renewal and promote differentiation p750

Amy A. Kiger, Helen White-Cooper and Margaret T. Fuller

doi:10.1038/35037606

First paragraph | Full Text | PDF (385K)

Somatic control over the germline stem cell lineage during Drosophila spermatogenesis p754

John Tran, Tamara J. Brenner and Stephen DiNardo

doi:10.1038/35037613

First paragraph | Full Text | PDF (347K)

The complete sequence of the mucosal pathogen Ureaplasma urealyticum p757

John I. Glass, Elliot J. Lefkowitz, Jennifer S. Glass, Cheryl R. Heiner, Ellson Y. Chen and Gail H. Cassell

doi:10.1038/35037619

First paragraph | Full Text | PDF (286K) | Supplementary information

Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms p762

Pradeep K. Singh, Amy L. Schaefer, Matthew R. Parsek, Thomas O. Moninger, Michael J. Welsh and E. P. Greenberg

doi:10.1038/35037627

First paragraph | Full Text | PDF (230K)

Messenger RNA targeting of rice seed storage proteins to specific ER subdomains p765

Sang-Bong Choi, Changlin Wang, Douglas G. Muench, Kenjirou Ozawa, Vincent R. Franceschi, Yujia Wu and Thomas W. Okita

doi:10.1038/35037633

First paragraph | Full Text | PDF (259K)

correction: BcL-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC p767

Shigeomi Shimizu, Masashi Narita and Yoshihide Tsujimoto

doi:10.1038/35037638

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Insight

Apoptosis p769

doi:10.1038/35037752

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The biochemistry of apoptosis p770

Michael O. Hengartner

doi:10.1038/35037710

Abstract | Full Text | PDF (649K)

Defying death after DNA damage p777

Tina Rich, Rachel L. Allen and Andrew H. Wyllie

doi:10.1038/35037717

Abstract | Full Text | PDF (360K)

Corpse clearance defines the meaning of cell death p784

John Savill and Valerie Fadok

doi:10.1038/35037722

Abstract | Full Text | PDF (257K)

CD95's deadly mission in the immune system p789

Peter H. Krammer

doi:10.1038/35037728

Abstract | Full Text | PDF (209K)

Apoptosis in development p796

Pascal Meier, Andrew Finch and Gerard Evan

doi:10.1038/35037734

Abstract | Full Text | PDF (191K)

Apoptosis in the nervous system p802

Junying Yuan and Bruce A. Yankner

doi:10.1038/35037739

Abstract | Full Text | PDF (476K)

From bench to clinic with apoptosis-based therapeutic agents p810

Donald W. Nicholson

doi:10.1038/35037747

Abstract | Full Text | PDF (805K)

New on the Market

The main attraction p817

Separating the blood, stirring the pot, using magnets.

doi:10.1038/35037676

Full Text | PDF (227K)