Opinion

Strategy for Framework 6 p545

The European Commission is embarking on plans for its next Framework programme of research and development. Linking it to a broader strategy is advisable, provided political goodwill is preserved.

doi:10.1038/35036704

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Pigs, society and opacity p545

International agencies need to learn the lessons of the past about ill-advised secrecy.

doi:10.1038/35036706

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News

US considers moves to relieve morale crisis at energy labs p547

Colin Macilwain

doi:10.1038/35036708

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Novartis axes UK transplant centre p547

Jessa Netting

doi:10.1038/35036712

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Researchers fight for access to Native American skeleton p548

Rex Dalton

doi:10.1038/35036714

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Reactor refit ignites debate on Japan's fusion strategy p549

Robert Triendl

doi:10.1038/35036717

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Genomics initiative to decipher 10,000 protein structures p549

Paul Smaglik

doi:10.1038/35036720

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US lab animals may win in lawsuit p549

Meredith Wadman

doi:10.1038/35036722

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Age wins as Tokyo revamps retirement rules p550

David Cyranoski

doi:10.1038/35036724

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Frozen body offers chance to travel back in time p550

Quirin Schiermeier and Katrin Stehle

doi:10.1038/35036727

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Experts question precautionary approach p551

Colin Macilwain

doi:10.1038/35036730

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French lab seeks recipe for success p551

Declan Butler

doi:10.1038/35036733

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News in brief p552

doi:10.1038/35036735

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News Feature

The sandman's secrets p554

Neuroscientists at last have a molecular handle on how the brain controls our daily cycle of sleep and wakefulness. This is opening a rich avenue of study that could lead to new therapies for sleep disorders, says Marina Chicurel.

Marina Chicurel

doi:10.1038/35036738

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A hundred million points of light p557

Covering a quarter of the sky, the Sloan Digital Sky Survey has a bright future as a key astronomical resource, says Govert Schilling.

Govert Schilling

doi:10.1038/35036744

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Correspondence

Legal confusion over 'cloning' risks throwing baby out with bathwater p559

Martin H. Johnson and Jacek Z. Kubiak

doi:10.1038/35036747

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'Benign neglect' of inner city led to TB epidemic p559

Deborah Wallace

doi:10.1038/35036749

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Loss of taxonomists is a threat to pest control p559

M.R. Wilson

doi:10.1038/35036751

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Commentary

Research, innovation and politics p561

What future for science and technology after this autumn's US elections?

doi:10.1038/35036753

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Book Reviews

Supersymmetric frontiers and beyond p563

Gian Francesco Giudice reviews Supersymmetry: Unveiling the Ultimate Laws of Nature by Gordon Kane

doi:10.1038/35036639

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Filling space–time p563

doi:10.1038/35036641

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The counting-house called to account p564

Steve Blinkhorn reviews How to Build a Mind by Igor Aleksander

doi:10.1038/35036644

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How the real victory went to science p565

Richard Rhodes reviews The Effect of Science on the Second World War by Guy Hartcup

doi:10.1038/35036647

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Science in culture p566

Alison Abbott reviews

doi:10.1038/35036650

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Millennium Essay

Magic beans p567

The Japanese invader that's good for you.

Vaclav Smil

doi:10.1038/35036653

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Futures

Programmable matter p569

How quantum wellstone ushered in our modern age.

Wil McCarthy

doi:10.1038/35036656

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News and Views

Uncertainty in climate change p571

Climate modelling has produced varying projections of possible global rises in temperature. A simple statistical method brings several such projections into closer agreement and includes an indication of potential accuracy.

Andrew J. Weaver and Francis W. Zwiers

doi:10.1038/35036659

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Cognitive science: The logic of human learning p572

Nick Chater

doi:10.1038/35036662

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Meteorites: The long trip to Earth p573

Clark R. Chapman

doi:10.1038/35036666

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100 and 50 years ago p575

doi:10.1038/35036668

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Bose–Einstein condensates: The next big thing p575

Josette Chen

doi:10.1038/35036670

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Immunology: Memory needs no reminders p576

Stephen Martin and Chris Goodnow

doi:10.1038/35036673

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Microbiology: Resolving a methane mystery p577

Edward F. DeLong

doi:10.1038/35036677

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Precision measurements: Optical clocks coming of age p579

Patrick Gill

doi:10.1038/35036680

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Brief Communications

Colour-enhancing protein in blue petals p581

Spectacular morning glory blooms rely on a behind-the-scenes proton exchanger.

Sachiko Fukada-Tanaka, Yoshishige Inagaki, Toshio Yamaguchi, Norio Saito and Shigeru Iida

doi:10.1038/35036683

First paragraph | Full Text | PDF (175K)

Materials science: Ti₃SiC₂ has negligible thermopower p581

H. -I. Yoo, M. W. Barsoum and T. El-Raghy

doi:10.1038/35036686

First paragraph | Full Text | PDF (175K)

Biomechanics: Asymmetric toes aid underwater swimming p582

L. Christoffer Johansson and Ulla M. Lindhe Norberg

doi:10.1038/35036689

First paragraph | Full Text | PDF (130K)

Germline DNA: Wheat mutation rate after Chernobyl p583

Olga Kovalchuk, Yuri E. Dubrova, Andrey Arkhipov, Barbara Hohn and Igor Kovalchuk

doi:10.1038/35036692

First paragraph | Full Text | PDF (115K)

Metabolic scaling: Energy constraints on carnivore diet p584

Brian K. McNab

doi:10.1038/35036695

First paragraph | Full Text | PDF (87K)

Review

Phytochromes and light signal perception by plants—an emerging synthesis p585

Harry Smith

doi:10.1038/35036500

Abstract | Full Text | PDF (157K)

Articles

Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins p592

Anna Lasorella, Michela Noseda, Mercedes Beyna and Antonio Iavarone

doi:10.1038/35036504

Abstract | Full Text | PDF (472K) | Supplementary information

Structural determinants of water permeation through aquaporin-1 p599

Kazuyoshi Murata, Kaoru Mitsuoka, Teruhisa Hirai, Thomas Walz, Peter Agre, J. Bernard Heymann, Andreas Engel and Yoshinori Fujiyoshi

doi:10.1038/35036519

Abstract | Full Text | PDF (932K)

Letters to Nature

Efficient delivery of meteorites to the Earth from a wide range of asteroid parent bodies p606

D. Vokrouhlický and P. Farinella

doi:10.1038/35036528

First paragraph | Full Text | PDF (139K)

See also: News and Views by Chapman

Trapping and emission of photons by a single defect in a photonic bandgap structure p608

Susumu Noda, Alongkarn Chutinan and Masahiro Imada

doi:10.1038/35036532

First paragraph | Full Text | PDF (216K)

Colloidal ordering from phase separation in a liquid- crystalline continuous phase p611

Jean-Christophe Loudet, Philippe Barois and Philippe Poulin

doi:10.1038/35036539

First paragraph | Full Text | PDF (358K)

Patterning of polymer-supported metal films by microcutting p613

Natalie Stutzmann, Theo A. Tervoort, Kees Bastiaansen and Paul Smith

doi:10.1038/35036545

First paragraph | Full Text | PDF (306K)

Quantifying the uncertainty in forecasts of anthropogenic climate change p617

Myles R. Allen, Peter A. Stott, John F. B. Mitchell, Reiner Schnur and Thomas L. Delworth

doi:10.1038/35036559

First paragraph | Full Text | PDF (134K)

See also: News and Views by Weaver & Zwiers

Pressure-induced changes in the compression mechanism of aluminous perovskite in the Earth's mantle p620

John P. Brodholt

doi:10.1038/35036565

First paragraph | Full Text | PDF (145K)

A marine microbial consortium apparently mediating anaerobic oxidation of methane p623

Antje Boetius, Katrin Ravenschlag, Carsten J. Schubert, Dirk Rickert, Friedrich Widdel, Armin Gieseke, Rudolf Amann, Bo Barker Jørgensen, Ursula Witte and Olaf Pfannkuche

doi:10.1038/35036572

First paragraph | Full Text | PDF (163K) | Supplementary information

See also: News and Views by DeLong

Modern freshwater microbialite analogues for ancient dendritic reef structures p626

Bernard Laval, Sherry L. Cady, John C. Pollack, Christopher P. McKay, John S. Bird, John P. Grotzinger, Derek C. Ford and Harry R. Bohm

doi:10.1038/35036579

First paragraph | Full Text | PDF (436K)

Minimization of Boolean complexity in human concept learning p630

Jacob Feldman

doi:10.1038/35036586

First paragraph | Full Text | PDF (176K) | Supplementary information

See also: News and Views by Chater

Skin abnormalities generated by temporally controlled RXR mutations in mouse epidermis p633

Mei Li, Arup Kumar Indra, Xavier Warot, Jacques Brocard, Nadia Messaddeq, Shigeaki Kato, Daniel Metzger and Pierre Chambon

doi:10.1038/35036595

First paragraph | Full Text | PDF (322K)

Memory B-cell persistence is independent of persisting immunizing antigen p636

Mitsuo Maruyama, Kong-Peng Lam and Klaus Rajewsky

doi:10.1038/35036600

First paragraph | Full Text | PDF (470K)

See also: News and Views by Martin & Goodnow

A common E2F-1 and p73 pathway mediates cell death induced by TCR activation p642

Natalie A. Lissy, Penny K. Davis, Meredith Irwin, William G. Kaelin and Steven F. Dowdy

doi:10.1038/35036608

First paragraph | Full Text | PDF (154K)

Role for the p53 homologue p73 in E2F-1-induced apoptosis p645

Meredith Irwin, Maria Carmen Marin, Andrew C. Phillips, Ratnam S. Seelan, David I. Smith, Wanguo Liu, Elsa R. Flores, Kenneth Y. Tsai, Tyler Jacks, Karen H. Vousden and William G. Kaelin Jr

doi:10.1038/35036614

First paragraph | Full Text | PDF (179K) | Supplementary information

S-RNase uptake by compatible pollen tubes in gametophytic self-incompatibility p649

Doan-Trung Luu, Xike Qin, David Morse and Mario Cappadocia

doi:10.1038/35036623

First paragraph | Full Text | PDF (167K)

The large-scale organization of metabolic networks p651

H. Jeong, B. Tombor, R. Albert, Z. N. Oltvai and A.-L. Barabási

doi:10.1038/35036627

First paragraph | Full Text | PDF (172K) | Supplementary information

erratum: Determining multiple length scales in rocks p654

Yi-Qiao Song, Seungoh Ryu and Pabitra N. Sen

doi:10.1038/35036635

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erratum: Glycosyltransferase activity of Fringe modulates Notch–Delta interactions p654

Katja Brücker, Lidia Perez, Henrik Clausen and Stephen Cohen

doi:10.1038/35036637

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New on the Market

Staying in sequence p655

DNA sequencing kit, including gels, plates and matrixes — or is it matrices?

doi:10.1038/35036698

Full Text | PDF (192K)

Careers and Recruitment

Western researchers reap rich rewards in eastern institutions p657

Heading east may not be everyone's cup of tea, but for those who do, the experience can pay dividends, says Diane Gershon.

Diane Gershon

doi:10.1038/35036757

Full Text | PDF (181K)

correction p658

doi:10.1038/35036761

Full Text | PDF (202K)