Opinion

A nut to crack a sledgehammer p115

Antidoping scientists are failing in their efforts to rid sport of performance-enhancing drugs. But there are no inherent technical obstacles — the problem is simply one of resources.

doi:10.1038/35025245

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Time for a truce? p115

Public bickering over a controversial theory on the origins of AIDS is generating more heat than light.

doi:10.1038/35025247

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News

Tests fail to support claims for origin of AIDS in polio vaccine p117

David Dickson

doi:10.1038/35025249

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Physicists haunted by hints of Higgs boson p118

Alison Abbott

doi:10.1038/35025291

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Gore pledges support for bioscience p118

Meredith Wadman

doi:10.1038/35025294

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Heavyweight academies take up the cause of US postdocs p119

Jessa Netting

doi:10.1038/35025252

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France finally picks Parisian site for new synchrotron p119

Declan Butler

doi:10.1038/35025255

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Neuroscientist to lead Salk Institute p120

Rex Dalton

doi:10.1038/35025258

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Drug-resistant HIV shows a worrying increase in the UK p120

Natasha Loder

doi:10.1038/35025260

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US panel draws blank on Gulf War symptoms p121

Meredith Wadman

doi:10.1038/35025263

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Global warming threatens extinction for many species p121

David Spurgeon

doi:10.1038/35025266

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News in brief p122

doi:10.1038/35025269

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News Feature

What price the Olympian ideal? p124

Without more money for their research, antidoping scientists will continue to be beaten into second place by pharmaceutically assisted athletes. Alison Abbott reports from the front line of sport's drugs war.

Alison Abbott

doi:10.1038/35025272

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The lot of the dope police p125

Alison Abbott

doi:10.1038/35025277

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A storm over steroids p126

Alison Abbott

doi:10.1038/35025280

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Correspondence

Step back to see how science and humanity fit in the big picture p128

Klaus Jaffe

doi:10.1038/35025284

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Patent dispute hangs over kringle 5 p128

Judah Folkman

doi:10.1038/35025286

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Commentary

When peer review fails p129

Problems with a giant laser project.

doi:10.1038/35025288

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Book Reviews

Sporting colours p131

Kenan Malik reviews Taboo: Why Black Athletes Dominate Sports and Why We're Afraid to Talk About It by Jon Entine

doi:10.1038/35025122

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At the edges of life p132

Knut Schmidt-Nielsen reviews Life at the Extremes: The Science of Survival by Frances Ashcroft

doi:10.1038/35025125

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From one extreme to another p132

doi:10.1038/35025127

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Surfing the nebulae, churning the waters p133

J. L. Heilbron reviews From Galaxies to Turbines: Science, Technology and the Parsons Family by W. Garrett Scaife

doi:10.1038/35025130

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Science in culture p134

Robert S. Root-Bernstein reviews

doi:10.1038/35025133

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Millennium Essay

Creative tension p135

What links Aristotle, William Blake, Darwin and GM crops?

Keith G. Davies

doi:10.1038/35025156

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Futures

Madame Bovary, c'est moi p137

Once upon a time, fiction required the suspension of disbelief.

Dan Simmons

doi:10.1038/35025159

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News and Views

Currents without borders p139

Following the discovery of superconductivity at liquid-nitrogen temperatures, the idea of making 'superwires' soon ran into problems. Structural impurities remain the main obstacle, but a high dose of calcium may be the answer.

Paul M. Grant

doi:10.1038/35025162

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100 and 50 years ago p140

doi:10.1038/35025165

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Atmospheric physics: Sky-high Asian imports p140

Heike Langenberg

doi:10.1038/35025167

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Neurobiology: Bundling up excitement p141

Jeffrey D. Rothstein

doi:10.1038/35025170

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Global change: Plankton cooled a greenhouse p143

Birger Schmitz

doi:10.1038/35025173

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Cell biology: The specifics of membrane fusion p144

Suzie J. Scales, Jason B. Bock and Richard H. Scheller

doi:10.1038/35025176

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X-ray astronomy: Imaging black holes p146

Nicholas White

doi:10.1038/35025179

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Signal transduction: Lipid rafts and insulin action p147

Michael P. Czech

doi:10.1038/35025183

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Daedalus: Vitamins and minerals p148

David Jones

doi:10.1038/35025186

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Brief Communications

Immunocontraception of African elephants p149

A humane method to control elephant populations without behavioural side effects.

R. A. Fayrer-Hosken, D. Grobler, J. J. Van Altena, H. J. Bertschinger and J. F. Kirkpatrick

doi:10.1038/35025136

First paragraph | Full Text | PDF (135K)

Evolutionary biology: Sexual conflict and speciation p149

Tom Tregenza, Roger K. Butlin and Nina Wedell

doi:10.1038/35025138

First paragraph | Full Text | PDF (135K)

reply: Sexual conflict and speciation p150

S. Gavrilets

doi:10.1038/35025140

First paragraph | Full Text | PDF (139K)

Sandwich films: Properties of a new soft magnetic material p150

S. X. Wang, N. X. Sun, M. Yamaguchi and S. Yabukami

doi:10.1038/35025142

First paragraph | Full Text | PDF (139K)

Virology: KSHV-like herpesviruses in chimps and gorillas p151

Vincent Lacoste, Philippe Mauclre, Guy Dubreuil, John Lewis, Marie-Claude Georges-Courbot and Antoine Gessain

doi:10.1038/35025145

First paragraph | Full Text | PDF (105K)

Addendum: Fish do not avoid survey vessels p152

P. G. Fernandes, A. S. Brierley, E. J. Simmonds, N. W. Millard, S. D. McPhail, F. Armstrong , P. Stevenson and M. Squires

doi:10.1038/35025149

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Article

Compartmental specificity of cellular membrane fusion encoded in SNARE proteins p153

James A. McNew, Francesco Parlati, Ryouichi Fukuda, Robert J. Johnston, Keren Paz, Fabienne Paumet, Thomas H. Söllner and James E. Rothman

doi:10.1038/35025000

Abstract | Full Text | PDF (294K)

See also: News and Views by Scales et al.

Letters to Nature

Laboratory detection of X-ray fringes with a grazing-incidence interferometer p160

Webster Cash, Ann Shipley, Steve Osterman and Marshall Joy

doi:10.1038/35025009

First paragraph | Full Text | PDF (162K)

See also: News and Views by White

Enhanced supercurrent density in polycrystalline YBa₂Cu ₃O_7- at 77 K from calcium doping of grain boundaries p162

G. Hammerl, A. Schmehl, R. R. Schulz, B. Goetz, H. Bielefeldt, C. W. Schneider, H. Hilgenkamp and J. Mannhart

doi:10.1038/35025014

First paragraph | Full Text | PDF (190K)

See also: News and Views by Grant

Thin films of fullerene-like MoS₂ nanoparticles with ultra-low friction and wear p164

Manish Chhowalla and Gehan A. J. Amaratunga

doi:10.1038/35025020

First paragraph | Full Text | PDF (301K)

Helical self-assembled polymers from cooperative stacking of hydrogen-bonded pairs p167

J. H. K. Ky Hirschberg, Luc Brunsveld, Aissa Ramzi, Jef A. J. M. Vekemans, Rint P. Sijbesma and E. W. Meijer

doi:10.1038/35025027

First paragraph | Full Text | PDF (440K) | Supplementary information

Termination of global warmth at the Palaeocene/Eocene boundary through productivity feedback p171

Santo Bains, Richard D. Norris, Richard M. Corfield and Kristina L. Faul

doi:10.1038/35025035

First paragraph | Full Text | PDF (237K)

See also: News and Views by Schmitz

Earthquake-induced changes in a hydrothermal system on the Juan de Fuca mid-ocean ridge p174

H. Paul Johnson, Michael Hutnak, Robert P. Dziak, Christopher G. Fox, Istvan Urcuyo, James P. Cowen, John Nabelek and Charles Fisher

doi:10.1038/35025040

First paragraph | Full Text | PDF (310K)

Bacterial photosynthesis in surface waters of the open ocean p177

Z. S. Kolber, C. L. Van Dover, R. A. Niederman and P. G. Falkowski

doi:10.1038/35025044

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Large-scale processes and the Asian bias in species diversity of temperate plants p180

Hong Qian and Robert E. Ricklefs

doi:10.1038/35025052

First paragraph | Full Text | PDF (202K)

Genetic evidence for female host-specific races of the common cuckoo p183

H. Lisle Gibbs, Michael D. Sorenson, Karen Marchetti, M. de L. Brooke, N. B. Davies and Hiroshi Nakamura

doi:10.1038/35025058

First paragraph | Full Text | PDF (184K)

WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra p186

Bert Hobmayer, Fabian Rentzsch, Kerstin Kuhn, Christoph M. Happel, Christoph Cramer von Laue, Petra Snyder, Ute Rothbächer and Thomas W. Holstein

doi:10.1038/35025063

First paragraph | Full Text | PDF (261K) | Supplementary information

Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons p189

Shigeo Takamori, Jeong Seop Rhee, Christian Rosenmund and Reinhard Jahn

doi:10.1038/35025070

First paragraph | Full Text | PDF (258K)

See also: News and Views by Rothstein

Topological restriction of SNARE-dependent membrane fusion p194

Francesco Parlati, James A. McNew, Ryouichi Fukuda, Rebecca Miller, Thomas H. Söllner and James E. Rothman

doi:10.1038/35025076

First paragraph | Full Text | PDF (446K)

See also: News and Views by Scales et al.

Functional architecture of an intracellular membrane t-SNARE p198

Ryouichi Fukuda, James A. McNew, Thomas Weber, Francesco Parlati, Thomas Engel, Walter Nickel, James E. Rothman and Thomas H. Söllner

doi:10.1038/35025084

First paragraph | Full Text | PDF (238K)

See also: News and Views by Scales et al.

CAP defines a second signalling pathway required for insulin-stimulated glucose transport p202

Christian A. Baumann, Vered Ribon, Makoto Kanzaki, Debbie C. Thurmond, Silvia Mora, Satoshi Shigematsu, Perry E. Bickel, Jeffrey E. Pessin and Alan R. Saltiel

doi:10.1038/35025089

First paragraph | Full Text | PDF (332K) | Supplementary information

See also: News and Views by Czech

Activation of heat-shock response by an adenovirus is essential for virus replication p207

Jolanta B. Glotzer, Mediyha Saltik, Susanna Chiocca, Anne-Isabelle Michou, Pope Moseley and Matt Cotten

doi:10.1038/35025102

First paragraph | Full Text | PDF (259K)

Peroxynitrite reductase activity of bacterial peroxiredoxins p211

Ruslana Bryk, Patrick Griffin and Carl Nathan

doi:10.1038/35025109

First paragraph | Full Text | PDF (234K)

Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase p215

John W. Trauger, Rahul M. Kohli, Henning D. Mootz, Mohamed A. Marahiel and Christopher T. Walsh

doi:10.1038/35025116

First paragraph | Full Text | PDF (156K)

Insight

Vascular biology p219

doi:10.1038/35025188

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A genetic blueprint for cardiac development p221

Deepak Srivastava and Eric N. Olson

doi:10.1038/35025190

Abstract | Full Text | PDF (298K)

Genomic circuits and the integrative biology of cardiac diseases p227

Kenneth R. Chien

doi:10.1038/35025196

Abstract | Full Text | PDF (377K)

Atherosclerosis p233

Aldons J. Lusis

doi:10.1038/35025203

Abstract | Full Text | PDF (1,458K)

Vascular-specific growth factors and blood vessel formation p242

George D. Yancopoulos, Samuel Davis, Nicholas W. Gale, John S. Rudge, Stanley J. Wiegand and Jocelyn Holash

doi:10.1038/35025215

Abstract | Full Text | PDF (436K)

Angiogenesis in cancer and other diseases p249

Peter Carmeliet and Rakesh K. Jain

doi:10.1038/35025220

Abstract | Full Text | PDF (787K)

Thrombin signalling and protease-activated receptors p258

Shaun R. Coughlin

doi:10.1038/35025229

Abstract | Full Text | PDF (256K)

Perspectives for vascular genomics p265

Edward M. Rubin and Alan Tall

doi:10.1038/35025236

Abstract | Full Text | PDF (303K)

Vascular biology: a route to novel cardiovascular drugs p270

Tommy Abrahamsson, Adriano Henney, German Camejo and Mikael Dohlsten

doi:10.1038/35025242

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New on the Market

Life in the Fas lane p271

A selection of reagents and reagent-handling devices.

doi:10.1038/35025152

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