Figures and Tables : Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase : Nature

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Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase

John D. McKinney, Kerstin Höner zu Bentrup, Ernesto J. Muñoz-Elías, Andras Miczak, Bing Chen, Wai-Tsing Chan, Dana Swenson, James C. Sacchettini, William R. Jacobs, Jr and David G. Russell

Nature 406, 735-738(17 August 2000)

doi:10.1038/35021074

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Figure 1

Absence of ICL does not affect growth or stationary phase survival in vitro.

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Figure 2

ICL is required for persistence and virulence of M. tuberculosis in immune-competent mice.

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Figure 3

The level of ICL–GFP is higher in bacteria within activated macrophages.

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Figure 4

The requirement for ICL is determined by the immune status of the host cell.

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Figure 5

The Delta icl mutant is lethal to immune-deficient mice.

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