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Opinion

Grounds for hope on AIDS in Africa p219

Despite the pervasive tension between AIDS researchers and the South African government, last week's international AIDS conference in Durban was successful on several fronts.

doi:10.1038/35018685


SOS (again) at the Department of Energy p219

Congress should provide adequate support for facilities operated on behalf of all US scientists.

doi:10.1038/35018687


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News

Large research facilities to lose out in science spending spree? p221

Colin Macilwain

doi:10.1038/35018689


Jordan chosen to open SESAME p221

Heather McCabe

doi:10.1038/35018693


UK space strategy slammed as lacking funds and vision p222

Natasha Loder

doi:10.1038/35018695


Cluster leaves the ground — at last p222

Natasha Loder

doi:10.1038/35018698


Diplomatic Mandela calls for action on HIV... p223

Michael Cherry

doi:10.1038/35018701


...as South Africa considers its options after free drugs offer p223

Michael Cherry

doi:10.1038/35018704


Diabetes therapy boosts stem-cell campaign p224

Paul Smaglik

doi:10.1038/35018706


Industry considers carbon catching p224

Steve Nadis

doi:10.1038/35018709


Enhanced advisory role urged for former EU nuclear labs p225

Quirin Schiermeier

doi:10.1038/35018711


Brown boosts British science base p225

Natasha Loder

doi:10.1038/35018714


Recriminations and confusion over 'fake' coelacanth photo p225

Heather McCabe

doi:10.1038/35018716


Anti-smoking critic wins campaigning right p226

Rex Dalton

doi:10.1038/35018718


German librarians cautious of brave new digital world p227

Quirin Schiermeier

doi:10.1038/35018721


News in brief p229

doi:10.1038/35018724


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News Feature

Bones, molecules...or both? p230

Evolutionary trees constructed by studying biological molecules often don't resemble those drawn up from morphology. Can the two ever be reconciled, asks Trisha Gura

Trisha Gura

doi:10.1038/35018729


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Correspondence

Caution is sensible, but give biotech a chance to show the good it can do p234

Enrico Porceddu

doi:10.1038/35018738


A fault in the 'weak San Andreas' theory p234

C. H. Scholz

doi:10.1038/35018740


That famous double helix takes a sinister turn p234

Colin Porter

doi:10.1038/35018742


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Book Reviews

The biotechnologist's jungle book p235

Walter Gratzer reviews Medicine Quest: In Search of Nature's Healing Secrets by Mark J. Plotkin

doi:10.1038/35018619


Healing hues p235

doi:10.1038/35018621


A function for dysfunction p236

Thomas J. Jentsch reviews Ion Channels and Disease by Frances M. Ashcroft

doi:10.1038/35018624


Channelling other energies p236

doi:10.1038/35018626


Conservation gets heavy p237

Rory Howlett reviews Hotspots: Earth's Biologically Richest and Most Endangered Terrestrial Ecoregions by Russell A. Mittermeier, Norman Myers and Cristina Goettsch Mittermeier

doi:10.1038/35018629


Chemistry's Canterbury Tales p238

John Emsley reviews A Chemical History Tour: Picturing Chemistry from Alchemy to Modern Molecular Science by Arthur Greenberg

doi:10.1038/35018632


New in paperback p238

doi:10.1038/35018634


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Millennium Essay

Jumbo p239

The revolutionary machine that shrank the world.

Vaclav Smil

doi:10.1038/35018651


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Futures

All is not lost p241

By resurrecting extinct infodiversity, we may save our own culture.

Scott Westerfeld

doi:10.1038/35018654


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News and Views

Faster than a speeding photon p243

The textbooks say nothing can travel faster than light, not even light itself. New experiments show that this is no longer true, raising questions about the maximum speed at which we can send information.

Jon Marangos

doi:10.1038/35018657


Biophysics: Science in motion p244

Philip Ball

doi:10.1038/35018660


Neurobiology: Parallel sensing p245

Mathew E. Diamond

doi:10.1038/35018663


Atmospheric physics: Enlightening water vapour p247

Brian J. Soden

doi:10.1038/35018666


Human behaviour: Fair game p248

Ruth Mace

doi:10.1038/35018669


Structural biology: Adding to the antifreeze agenda p249

Charles A. Knight

doi:10.1038/35018671


Mathematics: Best packing in proteins and DNA p251

Andrzej Stasiak and John H. Maddocks

doi:10.1038/35018674


100 and 50 years ago p252

doi:10.1038/35018677


Cell biology: A protein accumulator p253

Jennifer C. Pinder and Anthony J. Baines

doi:10.1038/35018679


Daedalus: Pulses of the mind p254

David Jones

doi:10.1038/35018683


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Brief Communications

Spider manipulation by a wasp larva p255

A parasitic wasp forces its host to weave a special web for its own ends.

William G. Eberhard

doi:10.1038/35018636


Phytochemistry: Heat-stable antifreeze protein from grass p256

Chris Sidebottom, Sarah Buckley, Paul Pudney, Sarah Twigg, Carl Jarman, Chris Holt, Julia Telford, Andrew McArthur, Dawn Worrall, Rod Hubbard and Peter Lillford

doi:10.1038/35018639

See also: News and Views by Knight


Cell differentiation: Hepatocytes from non-hepatic adult stem cells p257

Malcolm R. Alison, Richard Poulsom, Rosemary Jeffery, Amar P. Dhillon, Alberto Quaglia, Joe Jacob, Marco Novelli, Grant Prentice, Jill Williamson and Nicholas A. Wright

doi:10.1038/35018642


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Articles

Structure of the Fc fragment of human IgE bound to its high-affinity receptor FcepsilonRIalpha p259

Scott C. Garman, Beth A. Wurzburg, Svetlana S. Tarchevskaya, Jean-Pierre Kinet and Theodore S. Jardetzky

doi:10.1038/35018500


The 3.2-Å crystal structure of the human IgG1 Fc fragment–Fcbold gammaRIII complex p267

Peter Sondermann, Robert Huber, Vaughan Oosthuizen and Uwe Jacob

doi:10.1038/35018508


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Letters to Nature

Determining the ages of comets from the fraction of crystalline dust p275

Joseph A. Nuth, III, Hugh G. M. Hill and Gunther Kletetschka

doi:10.1038/35018516


Gain-assisted superluminal light propagation p277

L. J. Wang, A. Kuzmich and A. Dogariu

doi:10.1038/35018520

See also: News and Views by Marangos


Non-collinear states in magnetic sensors p280

Adrian Taga, Lars Nordström, Peter James, Börje Johansson and Olle Eriksson

doi:10.1038/35018528


Imaging the vortex-lattice melting process in the presence of disorder p282

Alex Soibel, Eli Zeldov, Michael Rappaport, Yuri Myasoedov, Tsuyoshi Tamegai, Shuuichi Ooi, Marcin Konczykowski and Vadim B. Geshkenbein

doi:10.1038/35018532


Optimal shapes of compact strings p287

Amos Maritan, Cristian Micheletti, Antonio Trovato and Jayanth R. Banavar

doi:10.1038/35018538

See also: News and Views by Stasiak & Maddocks


Evidence for a link between global lightning activity and upper tropospheric water vapour p290

Colin Price

doi:10.1038/35018543

See also: News and Views by Soden


Melting of the Earth's lithospheric mantle inferred from protactinium– thorium–uranium isotopic data p293

Yemane Asmerom, Hai Cheng, Rebecca Thomas, Marc Hirschmann and R. Lawrence Edwards

doi:10.1038/35018550


Female bluethroats enhance offspring immunocompetence through extra-pair copulations p296

Arild Johnsen, Vegard Andersen, Christine Sunding and Jan T. Lifjeld

doi:10.1038/35018556


Magnetite defines a vertebrate magnetoreceptor p299

Carol E. Diebel, Roger Proksch, Colin R. Green, Peter Neilson and Michael M. Walker

doi:10.1038/35018561


Transformation from temporal to rate coding in a somatosensory thalamocortical pathway p302

Ehud Ahissar, Ronen Sosnik and Sebastian Haidarliu

doi:10.1038/35018568

See also: News and Views by Diamond


Presenilin is required for proper morphology and function of neurons in C. elegans p306

Nicole Wittenburg, Stefan Eimer, Bernard Lakowski, Sascha Röhrig, Claudia Rudolph and Ralf Baumeister

doi:10.1038/35018575


A chemokine-driven positive feedback loop organizes lymphoid follicles p309

K. Mark Ansel, Vu N. Ngo, Paul L. Hyman, Sanjiv A. Luther, Reinhold Förster, Jonathon D. Sedgwick, Jeffrey L. Browning, Martin Lipp and Jason G. Cyster

doi:10.1038/35018581


A tertiary interaction that links active-site domains to the 5' splice site of a group II intron p315

Marc Boudvillain, Alexandre de Lencastre and Anna Marie Pyle

doi:10.1038/35018589


A ratchet-like inter-subunit reorganization of the ribosome during translocation p318

Joachim Frank and Rajendra Kumar Agrawal

doi:10.1038/35018597


Mimicry of ice structure by surface hydroxyls and water of a beta-helix antifreeze protein p322

Yih-Cherng Liou, Ante Tocilj, Peter L. Davies and Zongchao Jia

doi:10.1038/35018604


beta-Helix structure and ice-binding properties of a hyperactive antifreeze protein from an insect p325

Steffen P. Graether, Michael J. Kuiper, Stéphane M. Gagné, Virginia K. Walker, Zongchao Jia, Brian D. Sykes and Peter L. Davies

doi:10.1038/35018610


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New on the Market

Counting on proteomics p329

Download a trial of image analysis software, and seek those proteins.

doi:10.1038/35018645


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