FIGURE 1. BLC genomic locus and lack of BLC mRNA and protein in BLC-/- mice.
From the following article:
A chemokine-driven positive feedback loop organizes lymphoid follicles
K. Mark Ansel, Vu N. Ngo, Paul L. Hyman, Sanjiv A. Luther, Reinhold Förster, Jonathon D. Sedgwick, Jeffrey L. Browning, Martin Lipp and Jason G. Cyster
Nature 406, 309-314(20 July 2000)
doi:10.1038/35018581
a, BLC genomic locus before and after gene targeting. Black boxes indicate exons 1–4. The four cysteine residues are encoded by exons 2 and 3, as indicated. E, EcoR1; S, SacI; X, XhoI. b, Southern blot analysis of EcoR1-digested genomic DNA from +/+, +/- and -/- mice. c, Northern blot of total RNA from +/- and -/- spleen and mesenteric lymph node. d, Western blot of heparin precipitates from +/- and -/- spleen lysates for BLC. ctl, non-specific band detected with anti-BLC serum, shown as a loading control.
