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Nature 405, 903-904 (22 June 2000) | doi:10.1038/35016151

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Nutrition: Antioxidant activity of fresh apples

Marian V. Eberhardt1, Chang Yong Lee1 & Rui Hai Liu1

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Vitamin C is used as a dietary supplement because of its antioxidant activity, although a high dose (500 mg) may act as a pro-oxidant in the body1, 2. Here we show that 100 g of fresh apples has an antioxidant activity equivalent to 1,500 mg of vitamin C, and that whole-apple extracts inhibit the growth of colon- and liver- cancer cells in vitro in a dose-dependent manner. Our results indicate that natural antioxidants from fresh fruit could be more effective than a dietary supplement.