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Nature 405, 749-752 (15 June 2000) | doi:10.1038/35015654

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Cell biology: GTPase traffic control

Channing J. Der & William E. Balch

Each small GTP-hydrolysing enzyme (GTPase) of the Rho family regulates a huge variety of cellular processes. This implies that each protein can interact with many different downstream targets that bring about such processes.