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Nature 405, 627-628 (8 June 2000) | doi:10.1038/35015193
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Senior Computational Scientist
- Argonne National Laboratory
- Argonne, IL, United States
Faculty Positions
- University of Texas Medical Branch
- Galveston, TX United States
Alzheimer's disease: Closing in on 
-secretase
Bart De Strooper
For decades a short amyloid peptide known as A
has been invoked to
explain the neurodegeneration characteristic of Alzheimer's disease. This
peptide is generated from the amyloid precursor protein by protein-cleaving
(proteolytic) enzymes called -secretase and 
-secretase1
(Fig. 1
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