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Nature 405, 627-628 (8 June 2000) | doi:10.1038/35015193

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Alzheimer's disease: Closing in on big gamma-secretase

Bart De Strooper

For decades a short amyloid peptide known as Abeta has been invoked to explain the neurodegeneration characteristic of Alzheimer's disease. This peptide is generated from the amyloid precursor protein by protein-cleaving (proteolytic) enzymes called beta-secretase and gamma-secretase1 (Fig. 1