Opinion

Powerful visions for astronomy p379

US astronomers are getting better at forming a collective view of priorities. Their latest wish list is worth fighting for, but it is the process used to generate it that gives the community the best chance of attracting the necessary funds.

doi:10.1038/35013202

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Values of the abstract p379

A new set of prizes is an apt celebration of the significance and wonder to be found in pure mathematics.

doi:10.1038/35013204

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News

US astronomers draw up their wish list for a decade of funding p381

Tony Reichhardt

doi:10.1038/35013206

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France sets up élite Internet school p381

Heather McCabe

doi:10.1038/35013210

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Britain asks to join European Southern Observatory p382

David Dickson and Alison Abbott

doi:10.1038/35013212

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Mathematicians chase the seven million-dollar proofs p383

David Dickson

doi:10.1038/35013216

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BioMed Central boosted by editorial board p384

Declan Butler

doi:10.1038/35013218

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Russian PM supports science p384

Carl Levitin

doi:10.1038/35013221

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Congress wakes up to climate change p385

Colin Macilwain

doi:10.1038/35013224

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French unions upset by plans for physiology centre p385

Heather McCabe

doi:10.1038/35013227

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Bacterial AIDS vaccine ready for testing p386

Paul Smaglik

doi:10.1038/35013229

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Tax blow leaves Australian science reeling p387

Peter Pockley

doi:10.1038/35013232

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News in brief p388

doi:10.1038/35013235

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News Feature

Changing of the guard p389

Allan Bradley is to head the Sanger Centre, a powerhouse of the Human Genome Project. Trisha Gura asks how he will meet the challenges.

Trisha Gura

doi:10.1038/35013238

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Deep thoughts p390

North America is about to come under intense geophysical scrutiny. Rex Dalton explains how the four projects known as EarthScope will advance our understanding of volcanoes, fault systems and earthquakes.

Rex Dalton

doi:10.1038/35013242

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Correspondence

It's time to work together and stop duplicating conservation efforts ... p393

G. M. Mace, A. Balmford, L. Boitani, G. Cowlishaw, A. P. Dobson, D. P. Faith, K. J. Gaston, C. J. Humphries, R. I. Vane-Wright, P. H. Williams, J. H. Lawton, C. R. Margules, R. M. May, A. O. Nicholls, H. P. Possingham, C. Rahbek and A. S. van Jaarsveld

doi:10.1038/35013247

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... following Africa's lead in setting priorities p393

Gustavo A. B. da Fonseca, Andrew Balmford, Colin Bibby, Luigi Boitani, Fabio Corsi, Thomas Brooks, Claude Gascon, Silvio Olivieri, Russell A. Mittermeier, Neil Burgess, Eric Dinerstein, David Olson, Lee Hannah, Jon Lovett, David Moyer, Carsten Rahbek, Simon Stuart and Paul Williams

doi:10.1038/35013249

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Community groups could show Unesco the way p394

Gérard Toulouse

doi:10.1038/35013252

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Book Reviews

It won't come to the Crunch p395

Celebrate our new astronomical insight into the ultimate fate of the Universe.

William H. Press reviews The Runaway Universe: The Race to Find the Future of the Cosmos by Donald Goldsmith

doi:10.1038/35013122

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Dwarfed by space p395

doi:10.1038/35013124

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Stopping the tectonic conveyor belt p396

David Bercovici reviews Dynamic Earth: Plates, Plumes and Mantle Convection by Geoffrey F. Davies

doi:10.1038/35013127

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Magma event remembered p396

doi:10.1038/35013129

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A Gouldian valediction, almost p397

Henry Gee reviews The Lying Stones of Marrakech: Penultimate Reflections in Natural History by Stephen Jay Gould

doi:10.1038/35013132

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The many faces of science p397

Lisa Jardine reviews Defining Features: Scientific and Medical Portraits 1660–2000 by Ludmilla Jordanova

doi:10.1038/35013135

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New Journals p398

doi:10.1038/35013138

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Millennium Essay

Many paths to enlightenment p399

Modern physics bears the imprint of Western and Asian philosophies.

Susantha Goonatilake

doi:10.1038/35013162

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Futures

Brochure p401

The apocalypse: a great day out for the whole family.

Joe Haldeman

doi:10.1038/35013165

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News and Views

Palaeoclimate: Loophole for snowball Earth p403

The snowball Earth hypothesis posits an ice-covered planet. New climate simulations of 'snowball' conditions allow ice-free equatorial oceans that may be crucial for a theory about early animal evolution.

Bruce Runnegar

doi:10.1038/35013168

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Cancer: New link in a web of human genes p404

Jean Y. J. Wang

doi:10.1038/35013171

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Star formation: Three's a crowd p405

Alan P. Boss

doi:10.1038/35013174

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Genomic imprinting: Silence across the border p408

Wolf Reik and Adele Murrell

doi:10.1038/35013178

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100 and 50 years ago p409

doi:10.1038/35013182

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Seismology: Inner core takes another turn p411

Henri-Claude Nataf

doi:10.1038/35013184

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Ocean science: Carbon fixation p412

Jim Gillon

doi:10.1038/35013187

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Applied mathematics: The power of design p412

Mark Newman

doi:10.1038/35013189

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Neurobiology: Self-regulating synapses p413

Christine R. Rose and Arthur Konnerth

doi:10.1038/35013191

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Photonics: Opal appeal p414

Karen Southwell

doi:10.1038/35013194

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DNA repair: The bases for Cockayne syndrome p415

Philip C. Hanawalt

doi:10.1038/35013197

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Daedalus: The depths of madness p416

David Jones

doi:10.1038/35013200

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Brief Communications

Wireless capsule endoscopy p417

The discomfort of internal gastrointestinal examination may soon be a thing of the past.

Gavriel Iddan, Gavriel Meron, Arkady Glukhovsky and Paul Swain

doi:10.1038/35013140

First paragraph | Full Text | PDF (175K) | Supplementary information

Cell biology: Non-thermal heat-shock response to microwaves p417

David de Pomerai, Clare Daniells, Helen David, Joanna Allan, Ian Duce, Mohammed Mutwakil, David Thomas, Phillip Sewell, John Tattersall, Don Jones and Peter Candido

doi:10.1038/35013144

First paragraph | Full Text | PDF (454K)

Structural biology: Proton-powered turbine of a plant motor p418

Holger Seelert, Ansgar Poetsch, Norbert A. Dencher, Andreas Engel, Henning Stahlberg and Daniel J. Müller

doi:10.1038/35013148

First paragraph | Full Text | PDF (331K)

Progress

Roles of PPARs in health and disease p421

Sander Kersten, Béatrice Desvergne and Walter Wahli

doi:10.1038/35013000

Abstract | Full Text | PDF (172K)

Article

Neoproterozoic 'snowball Earth' simulations with a coupled climate/ice-sheet model p425

William T. Hyde, Thomas J. Crowley, Steven K. Baum and W. Richard Peltier

doi:10.1038/35013005

Abstract | Full Text | PDF (190K)

See also: News and Views by Runnegar

Letters to Nature

A triplet of differently shaped spin-zero states in the atomic nucleus ¹⁸⁶Pb p430

A. N. Andreyev, M. Huyse, P. Van Duppen, L. Weissman, D. Ackermann, J. Gerl, F. P. Hessberger, S. Hofmann, A. Kleinböhl, G. Münzenberg, S. Reshitko, C. Schlegel, H. Schaffner, P. Cagarda, M. Matos, S. Saro, A. Keenan, C. Moore, C. D. O'Leary, R. D. Page, M. Taylor, H. Kettunen, M. Leino, A. Lavrentiev, R. Wyss and K. Heyde

doi:10.1038/35013012

First paragraph | Full Text | PDF (205K)

Microdomain patterns from directional eutectic solidification and epitaxy p433

Claudio De Rosa, Cheolmin Park, Edwin L. Thomas and Bernard Lotz

doi:10.1038/35013018

First paragraph | Full Text | PDF (393K)

Large-scale synthesis of a silicon photonic crystal with a complete three-dimensional bandgap near 1.5 micrometres p437

Alvaro Blanco, Emmanuel Chomski, Serguei Grabtchak, Marta Ibisate, Sajeev John, Stephen W. Leonard, Cefe Lopez, Francisco Meseguer, Hernan Miguez, Jessica P. Mondia, Geoffrey A. Ozin, Ovidiu Toader and Henry M. van Driel

doi:10.1038/35013024

First paragraph | Full Text | PDF (265K)

Deep convective clouds with sustained supercooled liquid water down to -37.5 °C p440

Daniel Rosenfeld and William L. Woodley

doi:10.1038/35013030

First paragraph | Full Text | PDF (151K)

Past temperature and ¹⁸O of surface ocean waters inferred from foraminiferal Mg/Ca ratios p442

H. Elderfield and G. Ganssen

doi:10.1038/35013033

First paragraph | Full Text | PDF (217K)

Slow differential rotation of the Earth's inner core indicated by temporal changes in scattering p445

John E. Vidale, Doug A. Dodge and Paul S. Earle

doi:10.1038/35013039

First paragraph | Full Text | PDF (220K)

See also: News and Views by Nataf

Invasion sequence affects predator–prey dynamics in a multi-species interaction p448

Steven M. Sait, Wei-Chung Liu, David J. Thompson, H. Charles J. Godfray and Michael Begon

doi:10.1038/35013045

First paragraph | Full Text | PDF (160K) | Supplementary information

Chromosomal evolution in Saccharomyces p451

G. Fischer, S. A. James, I. N. Roberts, S. G. Oliver and E. J. Louis

doi:10.1038/35013058

First paragraph | Full Text | PDF (216K)

Synaptic activity at calcium-permeable AMPA receptors induces a switch in receptor subtype p454

Si-Qiong June Liu and Stuart G. Cull-Candy

doi:10.1038/35013064

First paragraph | Full Text | PDF (337K)

See also: News and Views by Rose & Konnerth

Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin p458

Lyudmila V. Borovikova, Svetlana Ivanova, Minghuang Zhang, Huan Yang, Galina I. Botchkina, Linda R. Watkins, Haichao Wang, Naji Abumrad, John W. Eaton and Kevin J. Tracey

doi:10.1038/35013070

First paragraph | Full Text | PDF (208K)

Targeted destabilization of HY5 during light-regulated development of Arabidopsis p462

Mark T. Osterlund, Christian S. Hardtke, Ning Wei and Xing Wang Deng

doi:10.1038/35013076

First paragraph | Full Text | PDF (286K)

Genomic rearrangement in NEMO impairs NF-B activation and is a cause of incontinentia pigmenti p466

and The International Incontinentia Pigmenti (IP) Consortium

doi:10.1038/35013114

First paragraph | Full Text | PDF (403K) | Supplementary information

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products p473

Song Zhao, Yi-Chinn Weng, Shyng-Shiou F. Yuan, Yi-Tzu Lin, Hao-Chi Hsu, Suh-Chin J. Lin, Elvira Gerbino, Mei-hua Song, Malgorzata Z. Zdzienicka, Richard A. Gatti, Jerry W. Shay, Yael Ziv, Yosef Shiloh and Eva Y.-H. P. Lee

doi:10.1038/35013083

First paragraph | Full Text | PDF (355K)

See also: News and Views by Wang

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response p477

Xiaohua Wu, Velvizhi Ranganathan, David S. Weisman, Walter F. Heine, David N. Ciccone, Ted B. O'Neill, Kindra E. Crick, Kerry A. Pierce, William S. Lane, Gary Rathbun, David M. Livingston and David T. Weaver

doi:10.1038/35013089

First paragraph | Full Text | PDF (300K) | Supplementary information

See also: News and Views by Wang

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene p482

Adam C. Bell and Gary Felsenfeld

doi:10.1038/35013100

First paragraph | Full Text | PDF (177K)

See also: News and Views by Reik & Murrell

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus p486

Amy T. Hark, Christopher J. Schoenherr, David J. Katz, Robert S. Ingram, John M. Levorse and Shirley M. Tilghman

doi:10.1038/35013106

First paragraph | Full Text | PDF (194K)

See also: News and Views by Reik & Murrell

New on the Market

Liquid refreshment p491

Top tips, filter tips, ergonomic tips and other takes on liquid handling.

doi:10.1038/35013152

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