Table of contents : Nature

Pools of latent HIV, lurking in the cells of infected people, remain untouched even by powerful drug combinations. Paul Smaglik reports on how this is forcing researchers to rethink their strategies for fighting the virus.

Paul Smaglik

doi:10.1038/35012712

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Correspondence

AIDS dissidents aren't victims — but the people their ideas kill will be p273

Edward Rybicki, Anna-Lise Williamson and Lynn Morris

doi:10.1038/35012786

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Bureaucracy strangles Latin American research p273

Julio E. Pérez and Abul K. Bashirullah

doi:10.1038/35012788

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Book Reviews

Emblem of a golden era p275

A physiologist's role in the coming of age of American biomedical science.

W. F. Bynum reviews Walter B. Cannon: Science and Society by Elin L. Wolfe, A. Clifford Barger and Saul Benison

doi:10.1038/35012671

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Expressions that stand the test of time p275

doi:10.1038/35012673

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Witness after the event p276

Mark Benecke reviews A Fly for the Prosecution: How Insect Evidence Helps Solve Crimes by M. Lee Goff

doi:10.1038/35012676

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Of viruses and men p277

Robin A. Weiss reviews Virus: The Co-discoverer of HIV Tracks its Rampage and Charts the Future by Luc Montagnier

doi:10.1038/35012683

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New in paperback p277

doi:10.1038/35012685

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Science in culture p278

Martin Kemp reviews

doi:10.1038/35012687

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Millennium Essay

More is less p279

Economists and governments lag decades behind Derek Price's thinking.

Terence Kealey

doi:10.1038/35012717

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Futures

Consequences p281

Perhaps the biotech sector should have employed more philosophers.

Poul Anderson

doi:10.1038/35012720

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News and Views

Recounting a genetic story p283

The DNA sequence of human chromosome 21, now published, provides indications that the total number of human genes has been overestimated, and is a valuable resource for research into Down syndrome.

Roger H. Reeves

doi:10.1038/35012790

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Astronomy: The comet no one saw p285

Michael F. A'Hearn

doi:10.1038/35012723

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100 and 50 years ago p285

doi:10.1038/35012726

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Cancer: Checkpoint for invasion p287

Lance A. Liotta and Timothy Clair

doi:10.1038/35012728

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Palaeoceanography: Nutrients in the glacial balance p288

Peggy Delaney

doi:10.1038/35012731

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Structural biology: Bioluminescence illuminated p291

Franklyn G. Prendergast

doi:10.1038/35012734

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Cell biology: Centrioles go for a stroll p292

Manfred Schliwa

doi:10.1038/35012738

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Materials science: Plastic sandwiches à la carte p293

Michael D. Ward

doi:10.1038/35012741

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Daedalus: Drink without drinking p294

David Jones

doi:10.1038/35012744

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Brief Communications

Guiding the swing in golf putting p295

Golfers control the pace of a putt by comparing sensory data with an internal guide.

C. M. Craig, D. Delay, M. A. Grealy and D. N. Lee

doi:10.1038/35012690

First paragraph | Full Text | PDF (126K)

Natural selection: Evolution of lifespan in C. elegans p296

David W. Walker, Gawain McColl, Nicole L. Jenkins, Jennifer Harris and Gordon J. Lithgow

doi:10.1038/35012693

First paragraph | Full Text | PDF (131K)

Auditory perception: How cicadas interpret acoustic signals p297

P. J. Fonseca, D. Münch and R. M. Hennig

doi:10.1038/35012696

First paragraph | Full Text | PDF (132K) | Supplementary information

Biotechniques: Transfection of cells by immunoporation p298

Lale Bildirici, Patricia Smith, Christos Tzavelas, Elina Horefti and David Rickwood

doi:10.1038/35012701

First paragraph | Full Text | PDF (185K)

erratum: Non-haemolytic -amino-acid oligomers p298

doi:10.1038/35012704

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Review

Lateral gene transfer and the nature of bacterial innovation p299

Howard Ochman, Jeffrey G. Lawrence and Eduardo A. Groisman

doi:10.1038/35012500

Abstract | Full Text | PDF (209K)

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Articles

Oceanic Cd/P ratio and nutrient utilization in the glacial Southern Ocean p305

H. Elderfield and R. E. M. Rickaby

doi:10.1038/35012507

Abstract | Full Text | PDF (255K)

The DNA sequence of human chromosome 21 p311

M. Hattori, A. Fujiyama, T. D. Taylor, H. Watanabe, T. Yada, H.-S. Park, A. Toyoda, K. Ishii, Y. Totoki, D.-K. Choi, E. Soeda, M. Ohki, T. Takagi, Y. Sakaki, S. Taudien, K. Blechschmidt, A. Polley, U. Menzel, J. Delabar, K. Kumpf, R. Lehmann, D. Patterson, K. Reichwald, A. Rump, M. Schillhabel, A. Schudy, W. Zimmermann, A. Rosenthal, J. Kudoh, K. Shibuya, K. Kawasaki, S. Asakawa, A. Shintani, T. Sasaki, K. Nagamine, S. Mitsuyama, S. E. Antonarakis, S. Minoshima, N. Shimizu, G. Nordsiek, K. Hornischer, P. Brandt, M. Scharfe, O. Schön, A. Desario, J. Reichelt, G. Kauer, H. Blöcker, J. Ramser, A. Beck, S. Klages, S. Hennig, L. Riesselmann, E. Dagand, T. Haaf, S. Wehrmeyer, K. Borzym, K. Gardiner, D. Nizetic, F. Francis, H. Lehrach, R. Reinhardt and M.-L. Yaspo

doi:10.1038/35012518

Abstract | Full Text | PDF (343K)

Letters to Nature

Discovery of a comet by its Lyman- emission p321

J. Teemu T. Mäkinen, Jean-Loup Bertaux, Harri Laakso, Tuija Pulkkinen, Tuula Summanen, Erkki Kyrölä, Walter Schmidt, Eric Quémerais and Rosine Lallement

doi:10.1038/35012526

First paragraph | Full Text | PDF (139K)

Thermally fluctuating superconductors in two dimensions p322

Subir Sachdev and Oleg A. Starykh

doi:10.1038/35012530

First paragraph | Full Text | PDF (172K)

Optical microscopy using a single-molecule light source p325

J. Michaelis, C. Hettich, J. Mlynek and V. Sandoghdar

doi:10.1038/35012545

First paragraph | Full Text | PDF (348K)

Intercalation of alkylamines into an organic polymer crystal p328

Akikazu Matsumoto, Toru Odani, Kazuki Sada, Mikiji Miyata and Kohji Tashiro

doi:10.1038/35012550

First paragraph | Full Text | PDF (242K) | Supplementary information

Constraining the atmospheric N₂O budget from intramolecular site preference in N₂O isotopomers p330

Naohiro Yoshida and Sakae Toyoda

doi:10.1038/35012558

First paragraph | Full Text | PDF (164K)

Simulated influences of Lake Agassiz on the climate of central North America 11,000 years ago p334

S. W. Hostetler, P. J. Bartlein, P. U. Clark, E. E. Small and A. M. Solomon

doi:10.1038/35012581

First paragraph | Full Text | PDF (898K)

Mesozoic plate-motion history below the northeast Pacific Ocean from seismic images of the subducted Farallon slab p337

Hans-Peter Bunge and Stephen P. Grand

doi:10.1038/35012586

First paragraph | Full Text | PDF (640K)

Functional diversity governs ecosystem response to nutrient enrichment p340

Florence D. Hulot, Gérard Lacroix, Françoise Lescher-Moutoué and Michel Loreau

doi:10.1038/35012591

First paragraph | Full Text | PDF (181K)

Adaptive plasticity in mate preference linked to differences in reproductive effort p344

Anna Qvarnström, Tomas Pärt and Ben C. Sheldon

doi:10.1038/35012605

First paragraph | Full Text | PDF (158K)

Cross-modal and cross-temporal association in neurons of frontal cortex p347

Joaquín M. Fuster, Mark Bodner and James K. Kroger

doi:10.1038/35012613

First paragraph | Full Text | PDF (239K)

Phenotypic suppression of empty spiracles is prevented by buttonhead p351

Frieder Schöck, Joachim Reischl, Ernst Wimmer, Heike Taubert, Beverly A. Purnell and Herbert Jäckle

doi:10.1038/35012620

First paragraph | Full Text | PDF (275K)

Blockade of RAGE–amphoterin signalling suppresses tumour growth and metastases p354

Akihiko Taguchi, David C. Blood, Gustavo del Toro, Anthony Canet, Daniel C. Lee, Wu Qu, Nozomu Tanji, Yan Lu, Evanthia Lalla, Caifeng Fu, Marion A. Hofmann, Thomas Kislinger, Mark Ingram, Amy Lu, Hidekazu Tanaka, Osamu Hori, Satoshi Ogawa, David M. Stern and Ann Marie Schmidt

doi:10.1038/35012626

First paragraph | Full Text | PDF (311K) | Supplementary information

Neurotoxicity induces cleavage of p35 to p25 by calpain p360

Ming-sum Lee, Young T. Kwon, Mingwei Li, Junmin Peng, Robert M. Friedlander and Li-Huei Tsai

doi:10.1038/35012636

First paragraph | Full Text | PDF (361K) | Supplementary information

LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway p364

Andrei G. Petcherski and Judith Kimble

doi:10.1038/35012645

First paragraph | Full Text | PDF (274K)

Translocation step size and mechanism of the RecBC DNA helicase p368

Piero R. Bianco and Stephen C. Kowalczykowski

doi:10.1038/35012652

First paragraph | Full Text | PDF (286K)

The crystal structure of the photoprotein aequorin at 2.3 Å resolution p372

James F. Head, Satoshi Inouye, Katsunori Teranishi and Osamu Shimomura

doi:10.1038/35012659

First paragraph | Full Text | PDF (302K)

Article

erratum: The ecological cost of sex p376

C. Patrick Doncaster, Graeme E. Pound and Simon J. Cox

doi:10.1038/35012667

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New on the Market

Catching the bug p377

A selection favouring microbiology — autoclaves, culture flasks and such.

doi:10.1038/35012707

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Table of contents

Volume 405 Number 6784 pp259-378

In this issue (18 May 2000)

Opinion

Benefits of increased public participation p259

News

Europe agrees to boost Internet networks used by researchers p261

A first Royal Society honour p261

Congo war increases threat to bonobo research p262

NIH takes charge of chimps infected in experiments p262

Cheaper AIDS drugs due for Third World... p263

...but South Africa voices reservations p263

Geneticist from Baylor named as new head of UK's Sanger Centre p264

Los Alamos labs are safe from fire p264

Researchers take a gamble on the human genome p264

Gene bank to offer family album of mammals p265

Japan calls for open access to human genome data p265

Greens persuade Europe to revoke patent on neem tree... p266

...as India pushes ahead with plant database p267

News in brief p268

News Feature

Reservoirs dog AIDS therapy p270