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Nature 404, 725-728 (13 April 2000) | doi:10.1038/35008000; Received 5 November 1999; Accepted 10 February 2000
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Specificities of heparan sulphate proteoglycans in developmental processes
Norbert Perrimon1 & Merton Bernfield2
Abstract
Heparan sulphate proteoglycans are abundant cell-surface molecules that consist of a protein core to which heparan sulphate glycosaminoglycan chains are attached. The functions of these molecules have remained mostly underappreciated by developmental biologists; however, the actions of important signalling molecules, for example Wnt and Hedgehog, depend on them. To understand both the mechanisms by which ligands involved in development interact with their receptors and how morphogens pattern tissues, biologists need to consider the functions of heparan sulphate proteoglycans in signalling and developmental patterning.
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