Opinion

Don't blame NASA alone for Mars mission failures p527

While the spotlight has been focused on mistakes by US space engineers and managers for the loss of recent Mars-bound spacecraft, others share responsibility. This includes those who have set unrealistic goals for the agency.

doi:10.1038/35007198

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Taking the initiative p527

Two new sections of Nature should help to keep readers informed and up to date on important areas of science.

doi:10.1038/35007200

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News

Complaints grow over delays in UK animal licence processing p529

Natasha Loder

doi:10.1038/35007202

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Japan sets tissue donor guidelines p529

Robert Triendl

doi:10.1038/35007205

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Varmus tells Congress to grasp thorny policy issues p530

Paul Smaglik

doi:10.1038/35007207

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US geneticists encouraged to play by the book p530

Meredith Wadman

doi:10.1038/35007210

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Global warming could be bad news for Arctic ozone layer p531

Peter Aldhous

doi:10.1038/35007212

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Japan squares up to conservationists over grey whale's status p531

Asako Saegusa

doi:10.1038/35007215

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US court tests the breadth of patent protection on proteins p532

Meredith Wadman

doi:10.1038/35007218

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Baja peninsula claims five victims in tragic accident p533

Rex Dalton and David Cyranoski

doi:10.1038/35007221

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Reshuffle lifts French synchrotron hopes p533

Heather McCabe

doi:10.1038/35007224

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Cereal gene bank accepts need for patents... p534

Rex Dalton

doi:10.1038/35007227

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... as Monsanto makes rice genome public p534

Declan Butler and Peter Pockley

doi:10.1038/35007230

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Is NASA paying the price of a dash for Mars? p535

Tony Reichhardt

doi:10.1038/35007232

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News in brief p536

doi:10.1038/35007235

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News Feature

Whatever happened to leptin? p538

Just five years ago, it seemed that a single protein might reverse the rising tide of obesity. What worked for mice has not yet translated to people. But watch this space, says Marina Chicurel.

Marina Chicurel

doi:10.1038/35007253

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Counting the cost of obesity p540

doi:10.1038/35007259

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Correspondence

Assessment mismatches must be sorted out: they leave species at risk p541

Craig Hilton-Taylor, Georgina M. Mace, David R. Capper, Nigel J. Collar, Simon N. Stuart, Colin J. Bibby, Caroline Pollock and Jørgen B. Thomsen

doi:10.1038/35007238

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Fooled, but not foolish p541

William L. Allen

doi:10.1038/35007241

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How much use is the Human Genome Project? p541

Sol Hadden

doi:10.1038/35007243

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Genes: we can't expect full understanding yet p542

Bruce Alberts and Aaron Klug

doi:10.1038/35007245

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Garlic study vindicated by official investigation p542

J. Koscielny, R. Schmitt, H. Radtke, R. Latza and H. Kiesewetter

doi:10.1038/35007247

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Learn lateral thinking first and specialize later p542

Nicholas J. Kuhn

doi:10.1038/35007249

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Religion has its place but don't pretend it's science p542

Lewis Wolpert

doi:10.1038/35007251

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Book Reviews

Tracking down a lethal inhalation p543

How a group of investigators unearthed the truth behind a Russian epidemic.

Ed Regis reviews Anthrax: The Investigation of a Deadly Outbreak by Jeanne Guillemin

doi:10.1038/35007121

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An education for climatologists p544

Robert E. Livezey reviews Statistical Analysis in Climate Research by Hans von Storch and Francis W. Zwiers

doi:10.1038/35007124

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Reviving the Doctor Universalis p544

Cynthia M. Pyle reviews Albertus Magnus "On Animals": A Medieval "Summa Zoologica", Vols 1 & 2 translated & annotated by Kenneth F. Kitchell, Jr and Irven Michael Resnick

doi:10.1038/35007126

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Recent references p544

doi:10.1038/35007128

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Father of the illustrated materia medica p545

doi:10.1038/35007130

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Something for everyone p545

Joan Roughgarden reviews An Illustrated Guide to Theoretical Ecology by Ted J. Case

doi:10.1038/35007133

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Science in culture p546

Martin Kemp reviews

doi:10.1038/35007135

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Millennium Essay

Abstraction and idealism p547

From Plato to Einstein: how do we acquire knowledge?

Semir Zeki

doi:10.1038/35007158

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Futures

The new laureate speaks p549

The response of this year's Nobelist in full

Charles Sheffield

doi:10.1038/35007161

Full Text | PDF (2,020K)

News and Views

When Greenland ice melts p551

Sea levels are likely to rise in response to global warming. But by how much? Identification of the causes of the six-metre surge during the last interglacial provides a useful clue.

Christine Schøtt Hvidberg

doi:10.1038/35007164

Full Text | PDF (165K)

Neurobiology: The good taste of genomics p552

Stuart Firestein

doi:10.1038/35007167

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100 and 50 years ago p553

doi:10.1038/35007170

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Urban climate: The water cooler p555

Jim Gillon

doi:10.1038/35007172

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Evolution: Bacterial cheaters p555

Joan E. Strassmann

doi:10.1038/35007175

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Magnetoresistance: A new spin on magnets p556

Thomas F. Rosenbaum

doi:10.1038/35007178

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Neurobiology: Dendrites go up, axons go down p557

Stephen M. Strittmatter

doi:10.1038/35007181

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Ornithology: British birds by number p559

Robert M. May

doi:10.1038/35007184

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Cell cycle: A new check on issuing the licence p560

J. Julian Blow and Shusuke Tada

doi:10.1038/35007187

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Astronomy: Two for the price of one p561

Sarah Tomlin

doi:10.1038/35007190

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Daedalus: The sharper image p561

David Jones

doi:10.1038/35007193

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Obituary: George Ledyard Stebbins (1906–2000) p562

Vassiliki Betty Smocovitis

doi:10.1038/35007195

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Brief Communications

Payment for labour in monkeys p563

Capuchins will voluntarily share treats with other monkeys that helped to secure them.

Frans B. M. de Waal and Michelle L. Berger

doi:10.1038/35007138

First paragraph | Full Text | PDF (95K)

Reproductive systems: Sex and the single lichen p564

G. J. Murtagh, P. S. Dyer and P. D. Crittenden

doi:10.1038/35007142

First paragraph | Full Text | PDF (142K)

Antibiotics: Non-haemolytic -amino-acid oligomers p565

Emilie A. Porter, Xifang Wang, Hee-Seung Lee, Bernard Weisblum and Samuel H. Gellman

doi:10.1038/35007145

First paragraph | Full Text | PDF (97K)

Fish behaviour: Stomach rinsing in rays p566

David W. Sims, Paul L. R. Andrews and J. Z. Young

doi:10.1038/35007149

First paragraph | Full Text | PDF (120K)

Article

Semaphorin 3A is a chemoattractant for cortical apical dendrites p567

Franck Polleux, Theresa Morrow and Anirvan Ghosh

doi:10.1038/35007001

Abstract | Full Text | PDF (584K) | Supplementary information

Letters to Nature

Identification of comet Hyakutake's extremely long ion tail from magnetic field signatures p574

Geraint H. Jones, André Balogh and Timothy S. Horbury

doi:10.1038/35007011

First paragraph | Full Text | PDF (185K)

Interception of comet Hyakutake's ion tail at a distance of 500 million kilometres p576

G. Gloeckler, J. Geiss, N. A. Schwadron, L. A. Fisk, T. H. Zurbuchen, F. M. Ipavich, R. von Steiger, H. Balsiger and B. Wilken

doi:10.1038/35007015

First paragraph | Full Text | PDF (239K)

A scalable quantum computer with ions in an array of microtraps p579

J. I. Cirac and P. Zoller

doi:10.1038/35007021

First paragraph | Full Text | PDF (161K)

Magnetoresistance from quantum interference effects in ferromagnets p581

N. Manyala, Y. Sidis, J. F. DiTusa, G. Aeppli, D.P. Young and Z. Fisk

doi:10.1038/35007030

First paragraph | Full Text | PDF (413K)

See also: News and Views by Rosenbaum

Communication at millimetre–submillimetre wavelengths using a ceramic ribbon p584

C. Yeh, F. Shimabukuro, P. Stanton, V. Jamnejad, W. Imbriale and F. Manshadi

doi:10.1038/35007036

First paragraph | Full Text | PDF (281K)

Functional hydrogel structures for autonomous flow control inside microfluidic channels p588

David J. Beebe, Jeffrey S. Moore, Joseph M. Bauer, Qing Yu, Robin H. Liu, Chelladurai Devadoss and Byung-Ho Jo

doi:10.1038/35007047

First paragraph | Full Text | PDF (232K)

Substantial contribution to sea-level rise during the last interglacial from the Greenland ice sheet p591

Kurt M. Cuffey and Shawn J. Marshall

doi:10.1038/35007053

First paragraph | Full Text | PDF (393K)

See also: News and Views by Hvidberg

Rapid and early export of Phaeocystis antarctica blooms in the Ross Sea, Antarctica p595

G. R. DiTullio, J. M. Grebmeier, K. R. Arrigo, M. P. Lizotte, D. H. Robinson, A. Leventer, J. P. Barry, M. L. VanWoert and R. B. Dunbar

doi:10.1038/35007061

First paragraph | Full Text | PDF (328K)

Developmental cheating in the social bacterium Myxococcus xanthus p598

Gregory J. Velicer, Lee Kroos and Richard E. Lenski

doi:10.1038/35007066

First paragraph | Full Text | PDF (179K)

See also: News and Views by Strassmann

A family of candidate taste receptors in human and mouse p601

Hiroaki Matsunami, Jean-Pierre Montmayeur and Linda B. Buck

doi:10.1038/35007072

First paragraph | Full Text | PDF (465K)

See also: News and Views by Firestein

High mobility of proteins in the mammalian cell nucleus p604

Robert D. Phair and Tom Misteli

doi:10.1038/35007077

First paragraph | Full Text | PDF (549K) | Supplementary information

PAR3 is a cofactor for PAR4 activation by thrombin p609

Mayumi Nakanishi-Matsui, Yao-Wu Zheng, David J. Sulciner, Ethan J. Weiss, Matthew J. Ludeman and Shaun R. Coughlin

doi:10.1038/35007085

First paragraph | Full Text | PDF (214K)

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway p613

Dae-Sik Lim, Seong-Tae Kim, Bo Xu, Richard S. Maser, Junyu Lin, John H.J. Petrini and Michael B. Kastan

doi:10.1038/35007091

First paragraph | Full Text | PDF (264K)

Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity p617

Elisabetta Bianchi, Simona Denti, Alessandra Granata, Giovanna Bossi, Jens Geginat, Antonello Villa, Lars Rogge and Ruggero Pardi

doi:10.1038/35007098

First paragraph | Full Text | PDF (307K)

XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis p622

Domenico Maiorano, Jacques Moreau and Marcel Méchali

doi:10.1038/35007104

First paragraph | Full Text | PDF (264K)

The Cdt1 protein is required to license DNA for replication in fission yeast p625

Hideo Nishitani, Zoi Lygerou, Takeharu Nishimoto and Paul Nurse

doi:10.1038/35007110

First paragraph | Full Text | PDF (309K)

See also: News and Views by Blow & Tada

erratum: Benzodiazepine actions mediated by specific -aminobutyric acid_A receptor subtypes p629

Uwe Rudolph, Florence Crestani, Dietmar Benke, Ina Brünig, Jack A. Benson, Jean-Marc Fritschy , James R. Martin, Horst Bluethmann and Hanns Möhler

doi:10.1038/35007116

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correction: Observation of a square flux-line lattice in the unconventional superconductor Sr₂RuO₄ p629

T. M. Riseman, P. G. Kealey, E. M. Forgan, A. P. Mackenzie, L. M. Galvin, A. W. Tyler, S. L. Lee, C. Ager, D. McK. Paul, C. M. Aegerter, R. Cubitt, Z. Q. Mao, T. Akima and Y. Maeno

doi:10.1038/35007118

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Insight

Obesity p631

Philip Campbell and Ritu Dhand

doi:10.1038/35007501

Full Text | PDF (1,532K)

Obesity in the new millennium p632

J. M. Friedman

doi:10.1038/35007504

Abstract | Full Text | PDF (1,387K)

Obesity as a medical problem p635

Peter G. Kopelman

doi:10.1038/35007508

Abstract | Full Text | PDF (2,297K)

Genetics of body-weight regulation p644

Gregory S. Barsh, I. Sadaf Farooqi and Stephen O'Rahilly

doi:10.1038/35007519

Abstract | Full Text | PDF (2,098K)

Towards a molecular understanding of adaptive thermogenesis p652

Bradford B. Lowell and Bruce M. Spiegelman

doi:10.1038/35007527

Abstract | Full Text | PDF (2,410K)

Central nervous system control of food intake p661

Michael W. Schwartz, Stephen C. Woods, Daniel Porte, Jr, Randy J. Seeley and Denis G. Baskin

doi:10.1038/35007534

Abstract | Full Text | PDF (3,715K)

Medicinal strategies in the treatment of obesity p672

George A. Bray and Louis A. Tartaglia

doi:10.1038/35007544

Abstract | Full Text | PDF (2,097K)

Roche and Obesity p678

Jonathan K.C. Knowles, Ph.D.

doi:10.1038/35007549

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New on the Market

Finding that gene p679

Genetic mapping, western blotting and DNA probes feature.

doi:10.1038/35007152

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Careers and Recruitment

Next-generation biologists must straddle computation and biology p683

Biological sciences are being transformed by the huge amounts of data emerging from newly sequenced genomes. But do the skills exist to cope?

Potter Wickware

doi:10.1038/35007262

Full Text | PDF (97K)

Multiple-degree dynamics p683

Potter Wickware

doi:10.1038/35007264

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Companies of all sizes are prospecting for proteins p684

Helen Gavaghan

doi:10.1038/35007267

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The power of prediction p685

Potter Wickware

doi:10.1038/35007271

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Training: United States gives priority to skills shortage p686

Bioinformatics marries together a wide range of scientific disciplines, but with a global shortage of skilled researchers, training is high on the agenda.

Potter Wickware

doi:10.1038/35007274

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Borrowing methods and models p687

Potter Wickware

doi:10.1038/35007276

Full Text | PDF (189K)

Training: Europe seeks solution to bioinformatics shortfall p687

Helen Gavaghan

doi:10.1038/35007279

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