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Brief Communications
Nature 404, 565 (6 April 2000) | doi:10.1038/35007145
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Account Director -India
- Indegene Lifesystems Pvt. Ltd
- Bengaluru 560 071 India
University Full-Professor (W3, Tenure Track)
- University of Münster
- Munster 48149 Germany
Antibiotics: Non-haemolytic 
-amino-acid oligomers
Emilie A. Porter1, Xifang Wang1, Hee-Seung Lee1, Bernard Weisblum2 & Samuel H. Gellman1
Abstract
Pathogenic bacteria are becoming increasingly resistant to common antibiotics,
stimulating an intensive search for new ones. Knowing that a class of medium-sized
peptides (magainins1) are widely used by host organisms as a
defence against microbial invasion2, we developed a 
-amino-acid
oligomer (-peptide) that mimics these natural antibiotics and tested
it for antimicrobial activity. We find not only that the activity of our -peptide
is comparable to that of a magainin derivative but also that it is effective
against four bacterial species, including two pathogens that are resistant
to common antibiotics.
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