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Nature 403, 720-721 (17 February 2000) | doi:10.1038/35001711

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Developmental biology: Raising the roof

Miguel Manzanares & Robb Krumlauf

In vertebrate embryos, the basic plan of the central nervous system forms as a precise network of neuronal cell types that are generated in ordered patterns in the developing neural tube. Two coordinated but partially independent patterning mechanisms assign positions along the anteroposterior and dorsoventral neural axes1, 2.