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Proteomics

Guilt-by-association goes global

Nature volume 403, pages 601–602 (2000)Cite this article

Clues to the function of a protein can be obtained by seeing whether it interacts with another protein of known function. This principle of guilt-by-association has now been applied to the entire protein complement of yeast.

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Figure 1: Levels of gene-function analysis.
Figure 2: Detection of protein associations in yeast using the two-hybrid system.

References

  1. Goffeau, A. et al. Science 274, 546–567 (1996).

    Article  ADS  CAS  Google Scholar 

  2. Fromont-Racine, M. et al. Nature Genet. 16, 277– 282 (1997).

    Article  CAS  Google Scholar 

  3. Mayes, A. E. et al. EMBO J. 18, 4321–4331 (1999).

    Article  CAS  Google Scholar 

  4. Flores, A. et al. Proc. Natl Acad. Sci. USA 96, 7815– 7820 (1999).

    Article  ADS  CAS  Google Scholar 

  5. Uetz, P. et al. Nature 403, 623–627 (2000).

    Article  ADS  CAS  Google Scholar 

  6. http://curatools.curagen.com

  7. Oliver, S. G. et al. Trends Biotechnol. 16, 373– 378 (1998).

    Article  CAS  Google Scholar 

  8. Hoheisel, J. D. Trends Biotechnol. 15, 465–469 (1997).

    Article  CAS  Google Scholar 

  9. Sagliocco, F. et al. Yeast 12, 1519–1534 (1996).

    Article  CAS  Google Scholar 

  10. Shevchenko, A. et al. Proc. Natl Acad. Sci. USA 93, 14440 –14445 (1996).

    Article  ADS  CAS  Google Scholar 

  11. Summerfield, S. G. et al. Int. J. Mass Spectrosc. 188, 1– 2 (1999).

    Article  Google Scholar 

  12. Link, A. J. et al. Nature Biotechnol. 17, 676– 682 (1999).

    Article  CAS  Google Scholar 

  13. Velculescu, V. E. et al. Cell 88, 243–251 (1997).

    Article  CAS  Google Scholar 

  14. Planta, R. J. et al. Yeast 15, 329–350 (1999).

    Article  CAS  Google Scholar 

  15. Teusink, B. et al. Methods Microbiol. 26, 297– 336 (1998).

    Article  CAS  Google Scholar 

  16. Brindle, K. et al. J. Mol. Recog. 10, 182– 187 (1997).

    Article  CAS  Google Scholar 

Download references

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  1. School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Oxford Road, Manchester, M13 9PT, UK

    Stephen Oliver

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Correspondence to Stephen Oliver.

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Oliver, S. Guilt-by-association goes global. Nature 403, 601–602 (2000). https://doi.org/10.1038/35001165

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