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Nature 403, 369-370 (27 January 2000) | doi:10.1038/35000309
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John Innes Centre Project Leader in Plant or Microbial Sciences
- University of East Anglia
- Norwich, NR4 7TJ, UK
Assistant or Associate Professor - Cell & Systems Biology
- University of Toronto
- Toronto, ON Canada
Neurobiology: Nogo in nerve regeneration
J. L. Goldberg1 & B. A. Barres1
Abstract
A protein long thought to inhibit the growth of regenerating nerve axons has at last been identified and cloned. This discovery could be an important step towards promoting nerve regeneration after stroke or spinal-cord injury.
Most tissues in the body — including muscle, skin, liver and peripheral nerve — have a remarkable ability to repair themselves after injury. Strangely, however, the brain and spinal cord, which constitute the central nervous system (CNS), have little innate capacity for repair.
- J. L. Goldberg and B. A. Barres are in the Department of Neurobiology, Stanford University School of Medicine, Fairchild Science Building, Stanford, California 94305, USA.
Correspondence to: J. L. Goldberg1 e-mails: Email: jlgoldbe@leland.stanford.edu
Correspondence to: B. A. Barres1 Email: barres@standford.edu
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