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Nature 403, 369-370 (27 January 2000) | doi:10.1038/35000309
Neurobiology: Nogo in nerve regeneration
J. L. Goldberg1 & B. A. Barres1
Abstract
A protein long thought to inhibit the growth of regenerating nerve axons has at last been identified and cloned. This discovery could be an important step towards promoting nerve regeneration after stroke or spinal-cord injury.
Most tissues in the body — including muscle, skin, liver and peripheral nerve — have a remarkable ability to repair themselves after injury. Strangely, however, the brain and spinal cord, which constitute the central nervous system (CNS), have little innate capacity for repair.
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