Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 403, 255-256 (20 January 2000) | doi:10.1038/35002220
Open Innovation Challenges
-
Optimizing Sub-cellular Localization Tags
The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression....
-
Methods of Modeling Adaptation in Populations
The analysis of adaptation with a population is a frequently encountered computational modeling scen...
- More Challenges
- Powered by:
nature jobs
Gastrointestinal Pathologist
- Brigham and Women's Hospital
- Boston, MA
Organic Chemistry
- Praj Matrix - Praj Industries Ltd
- Pune, Maharashtra Pune-411021 India
Signal transduction: A central control for cell growth
Alan J. Whitmarsh1 & Roger J. Davis1
Abstract
The identification of an unexpected function for the mitogen-activated protein kinase — the synthesis of DNA and RNA — opens up yet another route by which this multifaceted enzyme can influence cellular growth.
Cells respond to growth-promoting factors in two ways — by replicating their chromosomes and by increasing the expression of genes to form new proteins. Chromosome replication requires the production of new DNA, whereas the increase in gene expression requires synthesis of new ribonucleic acid (RNA).
- Alan J. Whitmarsh and Roger J. Davis are at the Howard Hughes Medical Institute, Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA.
Correspondence to: Roger J. Davis1 e-mail: Email: roger.davis@umassmed.edu
To read this story in full you will need to login or make a payment (see right).
