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Nature 402, 703 (16 December 1999) | doi:10.1038/45308

The promise of proteomics

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Analysing the entire set of proteins of an organism is a far bigger challenge than anything in genomics. The technological obstacles and biological complexities require, for now, a steady approach to that necessary goal.

The inside of a cell is a crowded and dynamic place, where proteins are perpetually being created and discarded. Understanding the structures, interactions and functions of all of a cell's or organism's proteins is one of the grand goals of the post-genomic era, and has been given a disciplinary title of its own: proteomics.