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Nature 402, 533-537 (2 December 1999) | doi:10.1038/990107;
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Faculty Positions in Cancer, Cardiovascular and Metabolic Diseases, Immunology
- Institute de Recherches Cliniques de Montreal
- Montreal, Quebec, Canada
Endowed Professorship
- Washington University School of Medicine in St. Louis
- St. Louis, MO 63110 United States
Membrane-anchored aspartyl protease with Alzheimer's disease |[beta]|-secretase activity
Mutations in the gene encoding the amyloid protein precursor (APP) cause autosomal dominant Alzheimer's disease. Cleavage of APP by unidentified proteases, referred to as β- and γ-secretases, generates the amyloid β-peptide, the main component of the amyloid plaques found in Alzheimer's disease patients.
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