Opinion

Human chromosome 22 and the virtues of collaboration p445

Two rival approaches to gene sequencing have demonstrated their complementarity with the fruitfly. For similar progress with the human genome, hostilities over data release policies should be re-examined.

doi:10.1038/44888

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In pursuit of broadband visions p445

Ambitious research agendas should stimulate vigorous demand for investment in broadband networks.

doi:10.1038/44890

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News

'Finishing' success marks major genome sequencing milestone ... p447

Declan Butler

doi:10.1038/44892

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... as researchers pounce on glut of data p447

Declan Butler

doi:10.1038/44895

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Tiny chromosome is rich in genes and medical promise p448

Natasha Loder

doi:10.1038/44897

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Unfinished sequence — the catch on 22 p448

Natasha Loder

doi:10.1038/44900

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US defence labs face research cutbacks... p449

Rex Dalton

doi:10.1038/44902

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...as Livermore blasted for laser project p449

Rex Dalton

doi:10.1038/44904

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EMBL rescue package keeps bioinformatics centre running p450

Alison Abbott

doi:10.1038/44907

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Centralized German research centres will compete for funds p450

Quirin Schiermeier

doi:10.1038/44910

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Nuclear safety and biotech boosted in Japan's budget p451

Asako Saegusa

doi:10.1038/44912

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Wellcome Trust backs Rutherford to host synchrotron p451

Natasha Loder

doi:10.1038/44914

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Opinion divided on images of Martian 'ocean' p452

Tony Reichhardt

doi:10.1038/44917

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South African telescope to go ahead p452

Michael Cherry

doi:10.1038/44920

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France cuts its 'big science' spend to bolster lab research p453

Heather McCabe

doi:10.1038/44922

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Champion of India's bomb rewarded with cabinet position p453

K. S. Jayaraman

doi:10.1038/44924

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EMBL pay settlement will cost millions p453

Alison Abbott

doi:10.1038/44927

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News in brief p454

doi:10.1038/44929

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Correspondence

This should not be the end for terminator technology in GM crops p457

Andrew Jackson and Chris Inglehearn

doi:10.1038/44931

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Weighing up the threat to the world's corals p457

Thomas J. Goreau

doi:10.1038/44933

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Who's doing what in US protein initiative p457

Marvin Cassman and Ari Patrinos

doi:10.1038/44935

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Search is on for better search engines p458

Vishwas Chavan

doi:10.1038/44937

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Japan builds bridges to rest of the world p458

Philippe Buhlmann

doi:10.1038/44939

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Galileo had accurate vision of the Moon p458

M. W. Friedlander

doi:10.1038/44941

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Book Reviews

Caught in the act p459

Forest life encapsulated in amber 20 million years ago can be reassembled.

S. Blair Hedges reviews The Amber Forest: A Reconstruction of a Vanished World by George Poinar, Jr and Roberta Poinar

doi:10.1038/44943

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Amber's contents p459

doi:10.1038/900007

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Knowledge on knowing p460

Manfred Fahle reviews The MIT Encyclopedia of the Cognitive Sciences

doi:10.1038/44946

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A blooming renaissance p460

Peter G. Kevan reviews The Rose's Kiss: A Natural History of Flowers

doi:10.1038/44948

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Research as 'normal' p461

Marco Finetti reviews Die Deutsche Forschungsgemeinschaft in der Weimarer Republik und im Dritten Reich — Wissenschaftspolitik in Republik und Diktatur 1920–1945 by Notker Hammerstein

doi:10.1038/44952

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Science in culture p462

J. L. Heilbron

doi:10.1038/44954

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Millennium Essay

Annus physicalis 1932 p463

A bumper crop of physical discoveries — something in the (heavy) water?

H. B. G. Casimir

doi:10.1038/44959

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Futures

COMP.BASILISK FAQ p465

Frequently asked questions about basilisks.

David Langford

doi:10.1038/44964

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News and Views

The book of genes p467

The sequence of human chromosome 22, now published, is the first phase in a biological revolution. Not least, the result will be a transformed appreciation of human individuality.

Peter Little

doi:10.1038/44967

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Mid-ocean ridges: One more time, from the top p469

Erik Hauri

doi:10.1038/44970

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Alzheimer's disease: A firm base for drug development p471

Bart De Strooper and Gerhard König

doi:10.1038/44973

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Chemical physics: Ultrafast relaxation in water p472

Abraham Nitzan

doi:10.1038/44976

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100 and 50 years ago p473

doi:10.1038/44979

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Neurobiology: Derailed axons get on track p475

Kai Zinn and Aloisia Schmid

doi:10.1038/44981

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Hearing: Spreading the fluid word p476

Jonathan Ashmore and Jessica de Boer

doi:10.1038/44985

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Daedalus: Happy landings p477

David Jones

doi:10.1038/44988

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Obituary: Thomas Hughes Jukes (1906–99) p478

John Maddox

doi:10.1038/44990

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Brief Communications

Precise dating of the Norfolk timber circle p479

This curious monument on the English coast has survived for more than four millennia.

Alex Bayliss, Cathy Groves, Gerry McCormac, Mike Baillie, Dave Brown and Mark Brennand

doi:10.1038/44993

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Transgenic plants: Insecticidal toxin in root exudates from Bt corn p480

Deepak Saxena, Saul Flores and G. Stotzky

doi:10.1038/44997

First paragraph | Full Text | PDF (185K)

Palaeobiology: Herbivorous diet in an ornithomimid dinosaur p480

Yoshitsugu Kobayashi, Jun-Chang Lu, Zhi-Ming Dong, Rinchen Barsbold, Yoichi Azuma and Yukimitsu Tomida

doi:10.1038/44999

First paragraph | Full Text | PDF (185K)

Reproduction: Germ cells colonized by endosymbiotic bacteria p482

Stephen J. Hadfield and J. Myles Axton

doi:10.1038/45002

First paragraph | Full Text | PDF (113K)

Progress

Synexpression groups in eukaryotes p483

Christof Niehrs and Nicolas Pollet

doi:10.1038/990025

Abstract | Full Text | PDF (612K)

Articles

The DNA sequence of human chromosome 22 p489

I. Dunham, A. R. Hunt, J. E. Collins, R. Bruskiewich, D. M. Beare, M. Clamp, L. J. Smink, R. Ainscough, J. P. Almeida, A. Babbage, C. Bagguley, J. Bailey, K. Barlow, K. N. Bates, O. Beasley, C. P. Bird, S. Blakey, A. M. Bridgeman, D. Buck, J. Burgess, W. D. Burrill, J. Burton, C. Carder, N. P. Carter, Y. Chen, G. Clark, S. M. Clegg, V. Cobley, C. G. Cole, R. E. Collier, R. E. Connor, D. Conroy, N. Corby, G. J. Coville, A. V. Cox, J. Davis, E. Dawson, P. D. Dhami, C. Dockree, S. J. Dodsworth, R. M. Durbin, A. Ellington, K. L. Evans, J. M. Fey, K. Fleming, L. French, A. A. Garner, J. G. R. Gilbert, M. E. Goward, D. Grafham, M. N. Griffiths, C. Hall, R. Hall, G. Hall-Tamlyn, R. W. Heathcott, S. Ho, S. Holmes, S. E. Hunt, M. C. Jones, J. Kershaw, A. Kimberley, A. King, G. K. Laird, C. F. Langford, M. A. Leversha, C. Lloyd, D. M. Lloyd, I. D. Martyn, M. Mashreghi-Mohammadi, L. Matthews, O. T. McCann, J. McClay, S. McLaren, A. A. McMurray, S. A. Milne, B. J. Mortimore, C. N. Odell, R. Pavitt, A. V. Pearce, D. Pearson, B. J. Phillimore, S. H. Phillips, R. W. Plumb, H. Ramsay, Y. Ramsey, L. Rogers, M. T. Ross, C. E. Scott, H. K. Sehra, C. D. Skuce, S. Smalley, M. L. Smith, C. Soderlund, L. Spragon, C. A. Steward, J. E. Sulston, R. M. Swann, M. Vaudin, M. Wall, J. M. Wallis, M. N. Whiteley, D. Willey, L. Williams, S. Williams, H. Williamson, T. E. Wilmer, L. Wilming, C. L. Wright, T. Hubbard, D. R. Bentley, S. Beck, J. Rogers, N. Shimizu, S. Minoshima, K. Kawasaki, T. Sasaki, S. Asakawa, J. Kudoh, A. Shintani, K. Shibuya, Y. Yoshizaki, N. Aoki, S. Mitsuyama, B. A. Roe, F. Chen, L. Chu, J. Crabtree, S. Deschamps, A. Do, T. Do, A. Dorman, F. Fang, Y. Fu, P. Hu, A. Hua, S. Kenton, H. Lai, H. I. Lao, J. Lewis, S. Lewis, S.-P. Lin, P. Loh, E. Malaj, T. Nguyen, H. Pan, S. Phan, S. Qi, Y. Qian, L. Ray, Q. Ren, S. Shaull, D. Sloan, L. Song, Q. Wang, Y. Wang, Z. Wang, J. White, D. Willingham, H. Wu, Z. Yao, M. Zhan, G. Zhang, S. Chissoe, J. Murray, N. Miller, P. Minx, R. Fulton, D. Johnson, G. Bemis, D. Bentley, H. Bradshaw, S. Bourne, M. Cordes, Z. Du, L. Fulton, D. Goela, T. Graves, J. Hawkins, K. Hinds, K. Kemp, P. Latreille, D. Layman, P. Ozersky, T. Rohlfing, P. Scheet, C. Walker, A. Wamsley, P. Wohldmann, K. Pepin, J. Nelson, I. Korf, J. A. Bedell, L. Hillier, E. Mardis, R. Waterston, R. Wilson, B. S. Emanuel, T. Shaikh, H. Kurahashi, S. Saitta, M. L. Budarf, H. E. McDermid, A. Johnson, A. C. C. Wong, B. E. Morrow, L. Edelmann, U. J. Kim, H. Shizuya, M. I. Simon, J. P. Dumanski, M. Peyrard, D. Kedra, E. Seroussi, I. Fransson, I. Tapia, C. E. Bruder and K. P. O'Brien

doi:10.1038/990031

Abstract | Full Text | PDF (410K) | Supplementary information

The temporal requirement for endothelin receptor-B signalling during neural crest development p496

Myung K. Shin, John M. Levorse, Robert S. Ingram and Shirley M. Tilghman

doi:10.1038/990040

Abstract | Full Text | PDF (298K)

Letters to Nature

Discovery of a massive equatorial torus in the Carinae stellar system p502

P. W. Morris, L. B. F. M. Waters, M. J. Barlow, T. Lim, A. de Koter, R. H. M. Voors, P. Cox, Th. de Graauw, Th. Henning, S. Hony, H. J. G. L. M. Lamers, H. Mutschke and N. R. Trams

doi:10.1038/990048

First paragraph | Full Text | PDF (606K)

Observation of spin and charge collective modes in one-dimensional metallic chains p504

P. Segovia, D. Purdie, M. Hengsberger and Y. Baer

doi:10.1038/990052

First paragraph | Full Text | PDF (399K)

Resonant intermolecular transfer of vibrational energy in liquid water p507

Sander Woutersen and Huib J. Bakker

doi:10.1038/990058

First paragraph | Full Text | PDF (123K)

Cyclic transmembrane charge transport by pyrylium ions in a vesicle-based photocatalytic system p509

Rafail F. Khairutdinov and James K. Hurst

doi:10.1038/990064

First paragraph | Full Text | PDF (153K)

Warming of the tropical Atlantic Ocean and slowdown of thermohaline circulation during the last deglaciation p511

Carsten Rühlemann, Stefan Mulitza, Peter J. Müller, Gerold Wefer and Rainer Zahn

doi:10.1038/990069

First paragraph | Full Text | PDF (334K)

The remelting of hydrothermally altered peridotite at mid-ocean ridges by intruding mantle diapirs p514

Mathieu Benoit, Georges Ceuleneer and Mireille Polvé

doi:10.1038/990073

First paragraph | Full Text | PDF (202K)

An early Cambrian craniate-like chordate p518

Jun-Yuan Chen, Di-Ying Huang and Chia-Wei Li

doi:10.1038/990080

First paragraph | Full Text | PDF (717K)

Sympatric speciation by sexual selection p523

M. Higashi, G. Takimoto and N. Yamamura

doi:10.1038/990087

First paragraph | Full Text | PDF (435K)

Direct measurement of intra-cochlear pressure waves p526

Elizabeth S. Olson

doi:10.1038/990092

First paragraph | Full Text | PDF (157K)

Stable propagation of synchronous spiking in cortical neural networks p529

Markus Diesmann, Marc-Oliver Gewaltig and Ad Aertsen

doi:10.1038/990101

First paragraph | Full Text | PDF (242K)

Membrane-anchored aspartyl protease with Alzheimer's disease -secretase activity p533

Riqiang Yan, Michael J. Bienkowski, Mary E. Shuck, Huiyi Miao, Monica C. Tory, Adele M. Pauley, John R. Brashler, Nancy C. Stratman, W. Rodney Mathews, Allen E. Buhl, Donald B. Carter, Alfredo G. Tomasselli, Luis A. Parodi, Robert L. Heinrikson and Mark E. Gurney

doi:10.1038/990107

First paragraph | Full Text | PDF (192K)

Purification and cloning of amyloid precursor protein -secretase from human brain p537

Sukanto Sinha, John P. Anderson, Robin Barbour, Guriqbal S. Basi, Russell Caccavello, David Davis, Minhtam Doan, Harry F. Dovey, Normand Frigon, Jin Hong, Kirsten Jacobson-Croak, Nancy Jewett, Pamela Keim, Jeroen Knops, Ivan Lieberburg, Michael Power, Hua Tan, Gwen Tatsuno, Jay Tung, Dale Schenk, Peter Seubert, Susanna M. Suomensaari, Shuwen Wang, Donald Walker, Jun Zhao, Lisa McConlogue and Varghese John

doi:10.1038/990114

First paragraph | Full Text | PDF (176K)

Axon routing across the midline controlled by the Drosophila Derailed receptor p540

Joshua L. Bonkowsky, Shingo Yoshikawa, David D. O'Keefe, Audra L. Scully and John B. Thomas

doi:10.1038/990122

First paragraph | Full Text | PDF (345K)

Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts p544

Andreas Wodarz, Andreas Ramrath, Ute Kuchinke and Elisabeth Knust

doi:10.1038/990128

First paragraph | Full Text | PDF (319K)

Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts p548

Markus Schober, Matthias Schaefer and Juergen A. Knoblich

doi:10.1038/990135

First paragraph | Full Text | PDF (210K)

A telomerase component is defective in the human disease dyskeratosis congenita p551

James R. Mitchell, Emily Wood and Kathleen Collins

doi:10.1038/990141

First paragraph | Full Text | PDF (225K)

The RCAF complex mediates chromatin assembly during DNA replication and repair p555

Jessica K. Tyler, Christopher R. Adams, Shaw-Ree Chen, Ryuji Kobayashi, Rohinton T. Kamakaka and James T. Kadonaga

doi:10.1038/990147

First paragraph | Full Text | PDF (392K)

New on the Market

A trick of the light p561

Lasers for tissue processing, imaging, measurement, ablation and so on.

doi:10.1038/45006

Full Text | PDF (152K)