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Volume 402 Issue 6761, 2 December 1999

Opinion

  • Two rival approaches to gene sequencing have demonstrated their complementarity with the fruitfly. For similar progress with the human genome, hostilities over data release policies should be re-examined.

    Opinion

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News

  • [LONDON]

    A professor of molecular medicine in London describes the complete sequence of chromosome 22 as “a fantastic resource for looking at human population genetics and disease gene susceptibility”.

    • Declan Butler
    News
  • [LONDON]

    While the published sequence of chromosome 22 is ‘almost complete’, filing the remaining gaps will be a daunting task.

    • Natasha Loder
    News
  • [SAN DIEGO]

    Mismanagement and poor planning have been blamed for significant cost overruns and delays in construction of the world's largest laser in California.

    • Rex Dalton
    News
  • [LONDON]

    Britain's Wellcome Trust has publicly declared its preference that a new synchrotron source should be built at the Rutherford Appleton Laboratory (RAL) in Oxfordshire.

    • Natasha Loder
    News
  • [WASHINGTON]

    Researchers remain split over whether a large ocean — or oceans — existed on Mars two billion years ago, when the planet was warmer and wetter.

    • Tony Reichhardt
    News
  • [CAPE TOWN]

    South Africa has given the green light for the construction of the largest single telescope for optical/infrared astronomy in the southern hemisphere.

    • Michael Cherry
    News
  • [NEW DELHI]

    A leading Indian rocket and missile scientists who was largely responsible for India's nuclear tests last year has been appointed principal science adviser to the government and given cabinet rank.

    • K. S. Jayaraman
    News
  • [MUNICH]

    A long-running labour dispute at the European Molecular Biology Laboratory has been settled through extra payments by its 16 member states.

    • Alison Abbott
    News
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News in Brief

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Correspondence

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Book Review

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Millennium Essay

  • A bumper crop of physical discoveries — something in the (heavy) water?

    • H. B. G. Casimir
    Millennium Essay
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Futures

  • Frequently asked questions about basilisks.

    • David Langford
    Futures
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News & Views

  • The sequence of human chromosome 22, now published, is the first phase in a biological revolution. This chromosome is the second smallest, and consists of some 33 million base pairs and as many as 1,000 genes. The projected date for sequencing all 23 chromosomes is 2002, and the eventual upshot of this revolution will be a transformed appreciation of human individuality.

    • Peter Little
    News & Views
  • The formation of crust at mid-ocean ridges is generally thought to involve the ascent and melting of mantle rocks, which erupt as basalt magmas and create crust. But evidence from an ophiolite — a ridge fragment preserved on land — points to the existence of a different process. It involves incursion of sea water into the top of the mantle, and repetitive melting of rocks to create andesite magma.

    • Erik Hauri
    News & Views
  • Alzheimer's disease is a progressive dementia in which massive protein deposits accumulate as either amyloid plaques or neurofibrillary tangles. The plaques are composed of a peptide called Aβ, which is liberated from its precursor, the amyloid precursor protein, by cleavage at two sites. The enzyme that cleaves at one of these sites, the β site, has now been identified, and it is likely to be a good target for drugs.

    • Bart De Strooper
    • Gerhard König
    News & Views
  • The study of chemical reactions is closely connected with the study of energy-relaxation processes. The discovery that an important energy-relaxation process in water is much faster than we thought means that vibrational energy gets dispersed too quickly in water to affect most chemical reactions.

    • Abraham Nitzan
    News & Views
  • How do growing axons in the central nervous system navigate through the jungle of cells that they encounteren routeto their targets? They are influenced by attractive and repulsive factors. One such factor, known as Derailed, is now shown to cause axon growth cones to head towards the so-called anterior commissure. It does so by repelling those axons that contain it from the posterior commissure.

    • Kai Zinn
    • Aloisia Schmid
    News & Views
  • The cochlea, found deep in the inner ear, detects sounds using an elaborately tuned basilar membrane. This membrane divides the cochlea lengthways into two fluid-filled compartments. To find out how fluid dynamics in these compartments affect hearing, scientists would like to measure the fluid flow and, although technically difficult, this has finally been done.

    • Jonathan Ashmore
    • Jessica de Boer
    News & Views
  • When things go wrong on an aircraft there is sometimes little the pilot can do to keep it in the air. Ideally, then, aircraft should be fitted with parachutes for a safe descent in the event of an emergency. In practice, a big enough parachute would occupy almost the whole interior of the plane, so Daedalus has a plan to deploy a small parachute, but one that descends a little faster than the aircraft just before it hits the ground.

    • David Jones
    News & Views
  • Tom Jukes: Nutritionist turned molecular biologist, who was a redoubtable opponent of creationism and claims for quack cures for cancer.

    • John Maddox
    News & Views
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Brief Communication

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Progress

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Article

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Letter

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New on the Market

  • Lasers for tissue processing, imaging, measurement, ablation and so on.

    New on the Market
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Collection

  • Forecasting the future in science is fun but often hopelessly misleading. This publication, commissioned by all the Naturejournals, focuses on future developments about which we can be reasonably confident and which will have an impact on the lives of all of us.

    Collection
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