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From the following article:

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

Riqiang Yan, Michael J. Bienkowski, Mary E. Shuck, Huiyi Miao, Monica C. Tory, Adele M. Pauley, John R. Brashler, Nancy C. Stratman, W. Rodney Mathews, Allen E. Buhl, Donald B. Carter, Alfredo G. Tomasselli, Luis A. Parodi, Robert L. Heinrikson and Mark E. Gurney

Nature 402, 533-537(2 December 1999)

doi:10.1038/990107

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Asp2 functional domains, tissue distribution and amino-acid sequence.

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Figure 2

Asp2 antisense oligomers decrease amyloid beta-peptide processing.

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Figure 3

Asp2 increases production of the APP C-terminal beta-secretase product.

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Figure 4

Asp2 increases Abeta peptide release.

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Figure 5

Asp2 beta-secretase cleavage activity.

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