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Brief Communications

Nature 402, 33-34 (4 November 1999) | doi:10.1038/46938

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Trans-gender induction of hair follicles

Amanda J. Reynolds1, Clifford Lawrence2, Peter B. Cserhalmi-Friedman3, Angela M. Christiano3 & Colin A. B. Jahoda1

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Human follicle cells can be induced to grow in an incompatible host of the other sex.

Adult hair growth and the cyclic regeneration of hair follicles are driven by finely regulated interactions between dermal and epidermal tissue at the base of the follicle1, 2. In rodents, isolated hair-follicle dermal cells that are reintroduced in vivo can induce new follicles3, 4, but this has never been achieved in humans.