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Nature 402, 30-31 (4 November 1999) | doi:10.1038/46925

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Signal transduction: Grabbing phosphoproteins

Michael B. Yaffe1 & Lewis C. Cantley1

The control of complex cellular events such as DNA repair, actin rearrangement, programmed cell death and transcriptional regulation requires acute orchestration of many signalling molecules, including kinases, phosphatases, proteases, guanine-nucleotide-binding (G) proteins and transcription factors. These molecules must relocate to specific sites in the cell, and their activities need to be regulated in a timely manner, often involving interactions with other proteins.

  1. Michael B. Yaffe and Lewis C. Cantley are in the Division of Signal Transduction, Harvard Medical School/Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.

Correspondence to: Michael B. Yaffe1 e-mail: Email: myaffe@caregroup.harvard.edu

Correspondence to: Lewis C. Cantley1 Email: cantley@helix.mgh.harvard.edu