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Nature 401, 748 (21 October 1999) | doi:10.1038/44476
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Protein crystallography: Frozen in time
Christopher Surridge
Biochemical reactions are extremely rapid, but the methods for imaging the enzymes that catalyse them can take hours. To get round this problem, structures can be determined at temperatures around 100 K, literally freezing an enzyme's movements and allowing the intermediates in its reaction cycle to be observed.
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