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Nature 401, 538-539 (7 October 1999) | doi:10.1038/44035
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Immunology: Wavering on commitment
Suzanne Cory
It has the garb of an authentic immature B lymphocyte, but this progenitor blood cell actually has other agendas. If it is denied the transcription factor Pax5, and so cannot proceed any further down the path towards becoming a mature antibody-producing cell, this versatile cell can instead become a T lymphocyte or a natural killer cell, or assume the guise of a number of different bone-marrow-derived cell types: an antigen-presenting dendritic cell, a bacterium-engulfing macrophage, a bone-resorbing osteoclast or even a bactericidal granulocyte.
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