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From the following article:

Cytochrome P450 2C is an EDHF synthase in coronary arteries

Beate Fisslthaler, Rüdiger Popp, Ladislau Kiss, Michael Potente, David R. Harder, Ingrid Fleming and Rudi Busse

Nature 401, 493-497(30 September 1999)

doi:10.1038/46816

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Increased expression of CYP 2C enhances EDHF-mediated relaxation of PCA and generation of 11,12-EET.

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Figure 2

Increased expression of CYP 2C enhances, and sulphaphenazole inhibits, the EDHF-mediated hyperpolarization of PCA.

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Figure 3

CYP 2C8/34 antisense oligonucleotides attenuate the expression of CYP 2C protein and the EDHF-mediated relaxation of PCA.

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Figure 4

CYP 2C antisense oligonucleotides abolish bradykinin-induced, EDHF-mediated hyperpolarization of PCA smooth muscle cells.

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