Opinion

How to boost the careers of women in science? p99

This week, Nature launches an international web debate on the factors that lead to the scarcity of women in research. Tackling discrimination is a high priority.

doi:10.1038/43494

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Emergency as opportunity p99

Powerful new leadership at France's troubled Natural History Museum should benefit organismal biology.

doi:10.1038/43496

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News

US energy secretary roasts tardy nuclear weapons laser project p101

Colin Macilwain

doi:10.1038/43498

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Chimp care causes furrowed brows p101

Rex Dalton

doi:10.1038/43501

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Japanese plan speeds up rice genome sequencing p102

Asako Saegusa

doi:10.1038/43503

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Physicists unite to combat a crisis of falling numbers p102

Heather McCabeH

doi:10.1038/43505

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India urged to lift map restrictions p102

K.S. Jayaraman

doi:10.1038/43508

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Clinton flails congress over $1.8 billion civilian R&D cuts p103

Colin Macilwain

doi:10.1038/43510

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Astronomers deflect scare-stories heading for media overkill p103

Steve Nadis

doi:10.1038/43513

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NASA could lose 'best-value space projects' p103

T. Reichhardt

doi:10.1038/43516

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France to renovate natural history museum p104

Declan Butler

doi:10.1038/43519

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Busquin targets young people p104

Keith Nuthall

doi:10.1038/43522

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Battle lines drawn between 'nanobacteria' researchers p105

Alison Abbott

doi:10.1038/43525

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Three Rs could make laboratories a better place for animals p106

Alison Abbott

doi:10.1038/43528

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Universities and business fight over right to information p106

Wil Lepkowski

doi:10.1038/43530

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Policy reversal puts science on top in New Zealand p106

Peter Pcokley

doi:10.1038/43532

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News Analysis

GM backlash leaves US farmers wondering how to sell their crops p107

American farmers have warmly embraced biotechnology. But resistance abroad and regulation at home are threatening to turn the affair sour.

Sally Lehrman

doi:10.1038/43536

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News in Brief p108

doi:10.1038/43539

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Correspondence

A science-oriented search engine could solve web problems ... p111

Mike Gardner

doi:10.1038/43541

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... just try to be specific ... p111

A.L.S. Chiu, E. Sherry and X. Phung

doi:10.1038/43543

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... using peer review as a guide to quality p111

Mike Fainzilber

doi:10.1038/43545

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Money, money, money p111

Barbara-Ann G. Lewis

doi:10.1038/43547

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Will Explore set the next century's standards? p111

Gillian Thomas

doi:10.1038/43549

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Spanish recruitment openly favours insiders p112

Javier Escartin

doi:10.1038/43551

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Spanish recruitment openly favours insiders p112

Javier Escartin

doi:10.1038/43551

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New opportunities for expert witnesses in court p112

Peter Fenn, Christine Jinks and Michael O'Shea

doi:10.1038/43553

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Book Reviews

Gatecrashing the nuclear club p113

India's 1998 nuclear-weapons tests heralded a second nuclear age.

Brahma Chellaney reviews Dr Strangelove, I Presume by Michael Foot and The Making of the Indian Atomic Bomb: Science, Secrecy and the Postcolonial State by Itty Abraham

doi:10.1038/43555

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Counting on our brains p114

Stanislas Dehaene reviews The Mathematical Brain by Brian Butterworth

doi:10.1038/43558

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Biochemistry: a biography p114

Charles Tanford and Jacqueline Reynolds review Proteins, Enzymes, Genes: The Interplay of Chemistry and Biology by Joseph S. Fruton

doi:10.1038/43560

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Alternative structure catalyses art market p115

doi:10.1038/43562

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Biology's structurally sound foundations p115

Gregory A. Petsko reviews Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding by Alan Fersht

doi:10.1038/43565

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Science in culture p116

Martin Kemp reviews Maculate Moons
Galileo and the Lunar Mountains

doi:10.1038/43567

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Millennium Essay

Moral calculus and the bomb p117

Targeting civilians, not using atomic weapons, was the moral watershed.

Kurt Gottfried

doi:10.1038/43571

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News and Views

Birds of a feather lek together p119

A lek looks like a winner-takes-all competition between males to attract females. But appearances could be deceptive, and the males might be a family group cooperating to their mutual evolutionary advantage.

Paul W. Sherman

doi:10.1038/43574

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Nanotechnology: Synthetic molecular motors p120

Anthony P. Davis

doi:10.1038/43576

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100 and 50 years ago p120

doi:10.1038/43580

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Cell biology: Lipid membranes shape up p123

Suzie J. Scales and Richard H. Scheller

doi:10.1038/43582

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Astronomy: Supernova birth for a black hole p124

John Cowan

doi:10.1038/43586

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Genomics: The millennium flies in p125

Kenneth C. Burtis and R. Scott Hawley

doi:10.1038/43589

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Apoptosis: Condensed matter in cell death p127

Naoufal Zamzami and Guido Kroemer

doi:10.1038/43591

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Daedalus: Weed insulation p128

David Jones

doi:10.1038/43595

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Brief Communications

Tropical tree gene flow and seed dispersal p129

Deforestation affects the genetic structure of the surviving forest fragments.

Matthew B. Hamilton

doi:10.1038/43597

First paragraph | Full Text | PDF (301K)

Internet: Diameter of the World-Wide Web p130

Réka Albert, Hawoong Jeong and Albert-László Barabási

doi:10.1038/43601

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Internet: Growth dynamics of the World-Wide Web p131

Bernardo A. Huberman and Lada A. Adamic

doi:10.1038/43604

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Genome evolution: Global methylation in eutherian hybrids p131

Irmgard Roemer, Frank Grützner, Heinz Winking, Thomas Haaf, Annie Orth, Lulu Skidmore, Doug Antczak and Reinald Fundele

doi:10.1038/43607

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reply: Genome evolution: Global methylation in eutherian hybrids p132

Rachel J. Waugh O'Neill, Michael J. O'Neill and Jennifer A. Marshall Graves

doi:10.1038/43611

First paragraph | Full Text | PDF (118K)

Article

Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid p133

Anne Schmidt, Michael Wolde, Christoph Thiele, Werner Fest, Hartmut Kratzin, Alexandre V. Podtelejnikov, Walter Witke, Wieland B. Huttner and Hans-Dieter Söling

doi:10.1038/43613

Abstract | Full Text | PDF (375K)

See also: News and Views by Scales & Scheller

Letters to Nature

Evidence of a supernova origin for the black hole in the system GRO J1655 - 40 p142

G. Israelian, R. Rebolo, G. Basri, J. Casares and E. L. Martín

doi:10.1038/43625

First paragraph | Full Text | PDF (196K)

See also: News and Views by Cowan

Charge fluctuations in YBa₂Cu₃O_7-x high-temperature superconductors p145

H. A. Mook and F. Doan

doi:10.1038/43629

First paragraph | Full Text | PDF (197K)

A ferromagnet having no net magnetic moment p148

H. Adachi and H. Ino

doi:10.1038/43634

First paragraph | Full Text | PDF (174K)

Unidirectional rotary motion in a molecular system p150

T. Ross Kelly, Harshani De Silva and Richard A. Silva

doi:10.1038/43639

First paragraph | Full Text | PDF (170K)

Light-driven monodirectional molecular rotor p152

Nagatoshi Koumura, Robert W. J. Zijlstra, Richard A. van Delden, Nobuyuki Harada and Ben L. Feringa

doi:10.1038/43646

First paragraph | Full Text | PDF (283K)

Peacocks lek with relatives even in the absence of social and environmental cues p155

Marion Petrie, Andrew Krupa and Terry Burke

doi:10.1038/43651

First paragraph | Full Text | PDF (137K)

See also: News and Views by Sherman

An epigenetic mutation responsible for natural variation in floral symmetry p157

Pilar Cubas, Coral Vincent and Enrico Coen

doi:10.1038/43657

First paragraph | Full Text | PDF (430K)

A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer p161

Sandrine Millet, Kenneth Campbell, Douglas J. Epstein, Kasia Losos, Esther Harris and Alexandra L. Joyner

doi:10.1038/43664

First paragraph | Full Text | PDF (276K)

The caudal limit of Otx2 expression positions the isthmic organizer p164

Vania Broccoli, Edoardo Boncinelli and Wolfgang Wurst

doi:10.1038/43670

First paragraph | Full Text | PDF (435K) | Supplementary information

Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation p168

Setsuko Sahara, Mamoru Aoto, Yutaka Eguchi, Naoko Imamoto, Yoshihiro Yoneda and Yoshihide Tsujimoto

doi:10.1038/43678

First paragraph | Full Text | PDF (408K)

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP p173

Kam Yeung, Thomas Seitz, Shengfeng Li, Petra Janosch, Brian McFerran, Christian Kaiser, Frances Fee, Kostas D. Katsanakis, David W. Rose, Harald Mischak, John M. Sedivy and Walter Kolch

doi:10.1038/43686

First paragraph | Full Text | PDF (237K)

Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle p177

Anita G. Seto, Arthur J. Zaug, Suzanne G. Sobel, Sandra L. Wolin and Thomas R. Cech

doi:10.1038/43694

First paragraph | Full Text | PDF (181K) | Supplementary information

Coherent reaction dynamics in a bacterial cytochrome c oxidase p181

Ursula Liebl, Gérard Lipowski, Michel Négrerie, Jean-Christophe Lambry, Jean-Louis Martin and Marten H. Vos

doi:10.1038/43699

First paragraph | Full Text | PDF (269K)

Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor p184

Christian Wiesmann, Mark H. Ultsch, Steven H. Bass and Abraham M. de Vos

doi:10.1038/43705

First paragraph | Full Text | PDF (377K)

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors p188

Michael S. Finnin, Jill R. Donigian, Alona Cohen, Victoria M. Richon, Richard A. Rifkind, Paul A. Marks, Ronald Breslow and Nikola P. Pavletich

doi:10.1038/43710

First paragraph | Full Text | PDF (448K)