When synaptic vesicles are recycled, they are 'pinched' off from the presynaptic membrane. A protein called dynamin was thought to be the 'pinchase', but it now turns out that dynamin's function is to recruit another protein, endophilin I, to the neck of the vesicle. Endophilin I affects the composition of the lipids in the vesicle's membrane, influencing its curvature and facilitating the pinching process.
- Suzie J. Scales
- Richard H. Scheller