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Nature 400, 116-117 (8 July 1999) | doi:10.1038/22006
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Senior Research Fellow - Atlantic Ocean Circulation and Climate
- University of Southampton
- Southampton / Hampshire United Kingdom
Head, Protein Production Unit
- The Novo Nordisk Foundation Center for Protein Research
- Copenhagen 2200 Denmark
Alzheimer's disease: Antibody clears senile plaques
Peter H. St George-Hyslop1 & David A. Westaway1
People suffering from Alzheimer's disease develop a progressive dementia in adulthood, accompanied by three main structural changes in the brain: diffuse loss of neurons in the hippocampus and neocortex; accumulation of intracellular protein deposits termed neurofibrillary tangles; and accumulation of extracellular protein deposits termed amyloid or senile plaques, surrounded by misshapen nerve terminals (dystrophic neurites). A main constituent of these amyloid plaques is the amyloid-
peptide (A), a 40-42-amino-acid protein that is produced through cleavage of the -amyloid precursor protein (APP).
- Peter H. St George-Hyslop and David A. Westaway are at the Centre for Research in Neurodegenerative Diseases, Departments of Medicine (Neurology) and Laboratory Medicine and Pathobiology, University of Toronto, 6 Queens Park Crescent West, Tanz Neuroscience Building, Toronto, Ontario M5S 3H2, Canada.
e-mail: Email: p.hyslop@utoronto.ca
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