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Nature 399, 739-740 (24 June 1999) | doi:10.1038/21550
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Alzheimer's disease: Pinning down phosphorylated tau
Michel Goedert1
A defining characteristic of several neurodegenerative diseases, including Alzheimer's disease and Pick's disease, is the formation of filamentous deposits of a microtubule-associated protein called tau in an abnormally hyperphosphorylated form. The discovery of mutations in the tau gene in a condition known as 'familial frontotemporal dementia and parkinsonism linked to chromosome 17' has renewed interest in the mechanisms by which dysfunction of tau causes neurodegeneration.
- Michel Goedert is at the MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
e-mail: Email: mg@mrc-lmb.cam.ac.uk
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