Table of contents
Volume 399 Number 6736 pp505-618
Opinion
Help! The data are coming p505
Some branches of science have learnt how to cope with huge amounts of information. Biologists haven't. There is a dearth of essential skills which is only now starting to be taken seriously.
doi:10.1038/20992
A cause worth funding p505
A German synchrotron would be good for the Middle East.
doi:10.1038/20994
News
Middle East synchrotron facility could bring regional cooperation p507
Ehsan Masood
doi:10.1038/20996
Pakistan prime minister pledges science boost p507
Ehsan Masood
doi:10.1038/20999
Biotech panel set up in US may help allay public fears p508
Tony Reichhardt
doi:10.1038/21001
German plan to curb rise in research funds p508
Quirin Schiermeier
doi:10.1038/21004
NASA tells physicists to aim for the stars p509
Colin Macilwain
doi:10.1038/21006
Varmus relaunches NIH degree proposal p509
Meredith Wadman
doi:10.1038/21009
Lawton named head of UK environment research agency p510
Ehsan Masood
doi:10.1038/21011
French research boosted by grants run by ministries p510
Eric Glover
doi:10.1038/21014
Funds promised for South African telescope p510
Michael Cherry
doi:10.1038/21016
Japan seeks targeted science funding ... p511
Asako Saegusa
doi:10.1038/21018
... and to use external scrutiny to increase competitiveness at universities p511
Asako Saegusa
doi:10.1038/21021
US jury split over hormone patent case ... p512
Rex Dalton
doi:10.1038/21023
... as Seeburg faces misconduct inquiry p512
Alison Abbott
doi:10.1038/21025
Astronomers win satellite phone curb... p513
Alison Abbott
doi:10.1038/21028
... and plan for talks on sharing the spectrum p513
Alison Abbott
doi:10.1038/21031
News
Conference wins the support of prominent politicians p516
doi:10.1038/21035
Ministers set to back promotion of science in Muslim countries p516
doi:10.1038/21037
Science academies 'should encourage ethics debates' p516
doi:10.1038/21039
Australian nominated for Unesco top job p516
doi:10.1038/21042
Briefings
It's sink or swim as a tidal wave of data approaches p517
Enormous amounts of data are being amassed in fields as diverse as genomics and astronomy. If this information is to be used effectively to speed the pace of discovery, scientists need new ways of working. This requires investment in computers, new statistical tools, and a liberal approach to data sharing.
doi:10.1038/21044
Data rescue fills in the climate record p518
Tony Reichhardt
doi:10.1038/21049
Catalogue of life could become reality p519
Tony Reichhardt
doi:10.1038/21051
Reaching for the digital sky p520
Tony Reichhardt
doi:10.1038/21053
Correspondence
Exploitation of junior scientists must end p521
Troy Shinbrot
doi:10.1038/21055
Lifting the lid on the homeobox discovery p521
Walter Gehring
doi:10.1038/21057
Longevity — does family size matter? p522
Toon Ligtenberg and Henk Brand
doi:10.1038/21059
City dwellers must share blame on biodiversity p522
A. J. Murdoch
doi:10.1038/21062
Biblical answer to cooking up pi p522
Kevin Peil
doi:10.1038/21064
News and Views
Shifting seas in the greenhouse? p523
Stefan Rahmstorf
doi:10.1038/21066
Antibiotic resistance: A vancomycin surprise p524
Michael S. Gilmore and James A. Hoch
doi:10.1038/21070
100 and 50 years ago p525
doi:10.1038/21073
Superconductivity: Cohabitation in the cuprates p527
Arthur P. Ramirez
doi:10.1038/21075
Ecology: Woodpecker population drills p528
Peter D. Moore
doi:10.1038/21078
Condensed-matter physics: Phases of resistance p529
Peter Littlewood
doi:10.1038/21083
Immunology: Looking out for memory T cells p531
Benedita Rocha
doi:10.1038/21086
Daedalus: Drawn from life p532
David Jones
doi:10.1038/21090
Scientific Correspondence
Hiding messages in DNA microdots p533
Catherine Taylor Clelland, Viviana Risca and Carter Bancroft
doi:10.1038/21092
First paragraph | Full Text | PDF (362K) | Supplementary information
Neurochemicals aid bee nestmate recognition p534
Gene E. Robinson, Laura M. Heuser, Yves LeConte, Frederic Lenquette and Robert M. Hollingworth
doi:10.1038/21095
First paragraph | Full Text | PDF (160K)
Parameters for global ecosystem models p535
Paul J. Crutzen, Ray Fall, Ian Galbally and Werner Lindinger
doi:10.1038/21098
First paragraph | Full Text | PDF (150K)
Parameters for global ecosystem models p535
Leif Schulman, Kalle Ruokolainen and Hanna Tuomisto
doi:10.1038/21100
First paragraph | Full Text | PDF (150K)
reply: Parameters for global ecosystem models p536
Hanqin Tian, Jerry M. Melillo, David W. Kicklighter, A. David McGuire, Berrien Moore, III and Charles J. Vörösmarty
doi:10.1038/21102
First paragraph | Full Text | PDF (120K)
Book Reviews
Apes and their place in our world p537
Mary Midgley reviews Brutal Kinship by Michael Nichols and Jane Goodall
doi:10.1038/21104
Telling it like it was p538
Peter T. Landsberg reviews Deep Time: How Humanity Communicates Across Millennia by Gregory Benford
doi:10.1038/21107
Explosion of interest p538
Martin Rudwick reviews Melting the Earth: The History of Ideas on Volcanic Eruptions by Haraldur Sigurdsson
doi:10.1038/21110
From tulips to electric cars p539
Patrick Tabeling reviews Arbres de Pierre: La Croissance Fractale de la Matière by Vincent Fleury
doi:10.1038/21113
Stumbling about the world of little things p540
Martin Wells reviews Waiting for Aphrodite by Sue Hubbell
doi:10.1038/21115
Review
Marine viruses and their biogeochemical and ecological effects p541
Jed A. Fuhrman
doi:10.1038/21119
Abstract | Full Text | PDF (272K)
Article
Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1 p549
Hongxu Qin, Srinivasa M. Srinivasula, Geng Wu, Teresa Fernandes-Alnemri, Emad S. Alnemri and Yigong Shi
doi:10.1038/21124
Abstract | Full Text | PDF (675K)
Letters to Nature
Detection of an impact-generated dust cloud around Ganymede p558
Harald Krüger, Alexander V. Krivov, Douglas P. Hamilton and Eberhard Grün
doi:10.1038/21136
First paragraph | Full Text | PDF (247K)
Percolative phase separation underlies colossal magnetoresistance in mixed-valent manganites p560
M. Uehara, S. Mori, C. H. Chen and S.-W. Cheong
doi:10.1038/21142
First paragraph | Full Text | PDF (273K)
Dynamics of individual flexible polymers in a shear flow p564
Philip LeDuc, Charbel Haber, Gang Bao and Denis Wirtz
doi:10.1038/21148
First paragraph | Full Text | PDF (277K)
Tuning bilayer twist using chiral counterions p566
R. Oda, I. Huc, M. Schmutz, S. J. Candau and F. C. MacKintosh
doi:10.1038/21154
First paragraph | Full Text | PDF (730K)
Causes of twentieth-century temperature change near the Earth's surface p569
Simon F. B. Tett, Peter A. Stott, Myles R. Allen, William J. Ingram and John F. B. Mitchell
doi:10.1038/21164
First paragraph | Full Text | PDF (197K) | Supplementary information
Changing spatial structure of the thermohaline circulation in response to atmospheric CO2 forcing in a climate model p572
Richard A. Wood, Ann B. Keen, John F. B. Mitchell and Jonathan M. Gregory
doi:10.1038/21170
First paragraph | Full Text | PDF (656K)
Feature-based attention influences motion processing gain in macaque visual cortex p575
Stefan Treue and Julio C. Martínez Trujillo
doi:10.1038/21176
First paragraph | Full Text | PDF (477K)
Poleward shifts in geographical ranges of butterfly species associated with regional warming p579
Camille Parmesan, Nils Ryrholm, Constantí Stefanescu, Jane K. Hill, Chris D. Thomas, Henri Descimon, Brian Huntley, Lauri Kaila, Jaakko Kullberg, Toomas Tammaru, W. John Tennent, Jeremy A. Thomas and Martin Warren
doi:10.1038/21181
First paragraph | Full Text | PDF (296K) | Supplementary information
Assignment of circadian function for the Neurospora clock gene frequency p584
Martha Merrow, Michael Brunner and Till Roenneberg
doi:10.1038/21190
First paragraph | Full Text | PDF (343K)
Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans p586
Robert Blelloch and Judith Kimble
doi:10.1038/21196
First paragraph | Full Text | PDF (617K)
Emergence of vancomycin tolerance in Streptococcus pneumoniae p590
R. Novak, B. Henriques, E. Charpentier, S. Normark and E. Tuomanen
doi:10.1038/21202
First paragraph | Full Text | PDF (242K)
Modelling T-cell memory by genetic marking of memory T cells in vivo p593
Joshy Jacob and David Baltimore
doi:10.1038/21208
First paragraph | Full Text | PDF (316K)
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt p597
David Fulton, Jean-Philippe Gratton, Timothy J. McCabe, Jason Fontana, Yasushi Fujio, Kenneth Walsh, Thomas F. Franke, Andreas Papapetropoulos and William C. Sessa
doi:10.1038/21218
First paragraph | Full Text | PDF (246K) | Supplementary information
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation p601
Stefanie Dimmeler, Ingrid Fleming, Beate Fisslthaler, Corinna Hermann, Rudi Busse and Andreas M. Zeiher
doi:10.1038/21224
First paragraph | Full Text | PDF (276K)
Enhancement of TBP binding by activators and general transcription factors p605
Xiao-Yong Li, Amy Virbasius, Xiaochuan Zhu and Michael R. Green
doi:10.1038/21232
First paragraph | Full Text | PDF (456K)
Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme p609
Laurent Kuras and Kevin Struhl
doi:10.1038/21239
First paragraph | Full Text | PDF (362K)
New on the Market
Microscopic advances p615
Nature' s annual New on the Market section devoted to matters
microscopic and to image analysis includes knives and microtomes, and 'prescription'
eyepieces to allow wearers of spectacles to use optical microscopes in comfort.
Compiled in the Nature office from information provided
by the manufacturers.
doi:10.1038/21246