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Nature 399, 524-527 (10 June 1999) | doi:10.1038/21070

Antibiotic resistance:  A vancomycin surprise

Michael S. Gilmore1 & James A. Hoch1

Vancomycin is the last line of defence against organisms such as Streptococcus pneumoniae and Enterococcus, some strains of which are resistant to most other antibiotics. Whereas S. pneumoniae