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Nature 399, 411-412 (3 June 1999) | doi:10.1038/20804
Apoptosis: Key to the mitochondrial gate
Jean-Claude Martinou
The mitochondrion, which was once thought simply to generate energy for a cell, is, in fact, a pivotal decision centre — it controls life and death by releasing death-promoting factors into the cytosol. One of these factors is cytochrome c, a protein that normally shuttles electrons between protein complexes in the inner mitochondrial membrane.
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