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Nature 399, 411-412 (3 June 1999) | doi:10.1038/20804

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Apoptosis:  Key to the mitochondrial gate

Jean-Claude Martinou

The mitochondrion, which was once thought simply to generate energy for a cell, is, in fact, a pivotal decision centre — it controls life and death by releasing death-promoting factors into the cytosol. One of these factors is cytochrome c, a protein that normally shuttles electrons between protein complexes in the inner mitochondrial membrane.

  1. Jean-Claude Martinou is at the Serono Pharmaceutical Research Institute, 14 chemin des Aulx, CH-1228 Plan-les-Ouates, Geneva, Switzerland.
    e-mail: Email: jean-claude.martinou@serono.com