FIGURE 3. Overview of metabolism and transport in T.maritima MSB8.

Pathways for energy production and the metabolism of organic compounds, acids and aldehydes are shown. Each gene product with a predicted function in ion or solute transport is illustrated. Transporters are grouped by substrate specificity according to role category: cations (green), anions (red), carbohydrates (yellow),purines (purple), amino acids/peptides/amines (dark blue) and other (light blue). Question marks associated with transporters indicate uncertainties in substrate specificity or direction of transport. Question marks associated with metabolic pathways indicate where an expected activity was not found. Permeases are represented by ovals. ABC transport systems are shown as composite figures of ovals, diamonds and circles. All other transporters are drawn as rectangles. Export or import of solutes is designated by the direction of the arrows through the transporter. If precise substrate specificity could not be determined for a transporter, no gene name was assigned and a more general common name reflecting the type of substrate being transported was used. Abbreviations: PRPP, phosphoribosyl-pyrophosphate; gly, glyceraldehyde; PEP, phosphoenolpyruvate; ATP, adenosine triphosphate; ADP, adenosine diphosphate; DHAP, dihydroxyacetone phosphate; OR, oxidoreductases; MCP, methyl-accepting chemotaxis protein; KDPG, 2-keto-3-deoxy-6-phosphogluconate; por, pyruvate oxidoreductase.