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Nature 399, 203-204 (20 May 1999) | doi:10.1038/20309

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Cancer:  Many vessels, faulty gene

William G. Kaelin, Jr1

Hereditary cancer syndromes can teach us much about the molecular circuits that are central to the life of a cancer cell. The genes responsible for these syndromes often encode proteins that act at critical points in the pathways controlling fundamental processes such as cell division, differentiation and death.

  1. William G. Kaelin Jr is at the Howard Hughes Medical Institute and Department of Adult Oncology, Dana-Farber Cancer Institute, and Departments of Medicine, Brigham and Womens Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
    e-mail: Email: william_kaelin@dfci.harvard.edu